PET studies of functional compensation in a primate model of Parkinson's disease

被引：37

作者：

Eberling, JL

Bankiewicz, KS

Jordan, S

VanBrocklin, HF

Jagust, WJ

机构：

[1] SOMATIX THERAPY CORP,ALAMEDA,CA

[2] MARTINEZ VA MED CTR,DEPT NEUROL,DAVIS,CA

[3] MARTINEZ VA MED CTR,DEPT NEUROL,DAVIS,CA

[4] UNIV CALIF DAVIS,DAVIS,CA

来源：

NEUROREPORT | 1997年 / 8卷 / 12期

关键词：

dopamine; FMT; MPTP; nigrostriata; Parkinson's disease; PET; putamen; substantia nigra;

D O I：

10.1097/00001756-199708180-00017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

MPTP 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is a neurotoxin that produces degeneration of nigrostriatal dopaminergic neurons and a chronic parkinsonian condition in primates. Positron emission tomography (PET) studies of rhesus macaques at various time points following unilateral MPTP administration demonstrated a different time course of degeneration in the dopaminergic terminals in the putamen and in the cell bodies in the substantia nigra, consistent with other evidence of retrograde degeneration. In addition, the substantia nigra showed a transient upregulation in dopaminergic function in the lesioned hemisphere indicating functional compensation. This plasticity has important implications for the therapeutic effects of growth factors and other. potential treatments for neurodegenerative diseases.

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收藏

页码：2727 / 2733

页数：7

相关论文

共 25 条

[1] CHRONIC ADMINISTRATION OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE TO MONKEYS - BEHAVIORAL, MORPHOLOGICAL AND BIOCHEMICAL CORRELATES [J].

ALBANESE, A ;

GRANATA, R ;

GREGORI, B ;

PICCARDI, MP ;

COLOSIMO, C ;

TONALI, P .

NEUROSCIENCE, 1993, 55 (03) :823-832

[2]

BANKIEWICZ KS, 1986, LIFE SCI, V39, P7, DOI 10.1016/0024-3205(86)90431-5

[3] A PRIMATE MODEL OF PARKINSONISM - SELECTIVE DESTRUCTION OF DOPAMINERGIC-NEURONS IN THE PARS COMPACTA OF THE SUBSTANTIA NIGRA BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE [J].

BURNS, RS ;

CHIUEH, CC ;

MARKEY, SP ;

EBERT, MH ;

JACOBOWITZ, DM ;

KOPIN, IJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (14) :4546-4550

[4] PRIMATE MODEL OF PARKINSONISM - SELECTIVE LESION OF NIGROSTRIATAL NEURONS BY 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE PRODUCES AN EXTRAPYRAMIDAL SYNDROME IN RHESUS-MONKEYS [J].

CHIUEH, CC ;

BURNS, RS ;

MARKEY, SP ;

JACOBOWITZ, DM ;

KOPIN, IJ .

LIFE SCIENCES, 1985, 36 (03) :213-218

[5] PARGYLINE AND DEPRENYL PREVENT THE NEUROTOXICITY OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) IN MONKEYS [J].

COHEN, G ;

PASIK, P ;

COHEN, B ;

LEIST, A ;

MYTILINEOU, C ;

YAHR, MD .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1984, 106 (01) :209-210

[6] CHRONIC PARKINSONISM SECONDARY TO INTRAVENOUS-INJECTION OF MEPERIDINE ANALOGS [J].

DAVIS, GC ;

WILLIAMS, AC ;

MARKEY, SP ;

EBERT, MH ;

CAINE, ED ;

REICHERT, CM ;

KOPIN, IJ .

PSYCHIATRY RESEARCH, 1979, 1 (03) :249-254

[7] SYMPTOMATIC AND ASYMPTOMATIC 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-TREATED PRIMATES - BIOCHEMICAL-CHANGES IN STRIATAL REGIONS [J].

ELSWORTH, JD ;

DEUTCH, AY ;

REDMOND, DE ;

TAYLOR, JR ;

SLADEK, JR ;

ROTH, RH .

NEUROSCIENCE, 1989, 33 (02) :323-331

[8] MPTP-INDUCED PARKINSONISM - RELATIVE CHANGES IN DOPAMINE CONCENTRATION IN SUBREGIONS OF SUBSTANTIA NIGRA, VENTRAL TEGMENTAL AREA AND RETRORUBRAL FIELD OF SYMPTOMATIC AND ASYMPTOMATIC VERVET MONKEYS [J].

ELSWORTH, JD ;

DEUTCH, AY ;

REDMOND, DE ;

SLADEK, JR ;

ROTH, RH .

BRAIN RESEARCH, 1990, 513 (02) :320-324

[9]

FIRNAU G, 1991, J LABEL COMP RADIOPH, V30, P272

[10] INCREASED DOPAMINE SYNTHESIS IN AGING SUBSTANTIA-NIGRA NEURONS [J].

GREENWOOD, CE ;

TATTON, WG ;

SENIUK, NA ;

BIDDLE, FG .

NEUROBIOLOGY OF AGING, 1991, 12 (05) :557-565