PARGYLINE AND DEPRENYL PREVENT THE NEUROTOXICITY OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) IN MONKEYS

被引：279

作者：

COHEN, G ^{[1
]}

PASIK, P ^{[1
]}

COHEN, B ^{[1
]}

LEIST, A ^{[1
]}

MYTILINEOU, C ^{[1
]}

YAHR, MD ^{[1
]}

机构：

[1] CUNY MT SINAI SCH MED,GRAD PROGRAM NEUROBIOL,NEW YORK,NY 10029

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1984年 / 106卷 / 01期

关键词：

D O I：

10.1016/0014-2999(84)90700-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：209 / 210

页数：2

共 5 条

[1] A PRIMATE MODEL OF PARKINSONISM - SELECTIVE DESTRUCTION OF DOPAMINERGIC-NEURONS IN THE PARS COMPACTA OF THE SUBSTANTIA NIGRA BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE [J].

BURNS, RS ;

CHIUEH, CC ;

MARKEY, SP ;

EBERT, MH ;

JACOBOWITZ, DM ;

KOPIN, IJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (14) :4546-4550

[2] METABOLISM OF THE NEUROTOXIC TERTIARY AMINE, MPTP, BY BRAIN MONOAMINE-OXIDASE [J].

CHIBA, K ;

TREVOR, A ;

CASTAGNOLI, N .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (02) :574-578

[3]

Cohen G, 1983, J Neural Transm Suppl, V19, P89

[4] CHRONIC PARKINSONISM IN HUMANS DUE TO A PRODUCT OF MEPERIDINE-ANALOG SYNTHESIS [J].

LANGSTON, JW ;

BALLARD, P ;

TETRUD, JW ;

IRWIN, I .

SCIENCE, 1983, 219 (4587) :979-980

[5] 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE DESTROYS DOPAMINE NEURONS IN EXPLANTS OF RAT EMBRYO MESENCEPHALON [J].

MYTILINEOU, C ;

COHEN, G .

SCIENCE, 1984, 225 (4661) :529-531

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