Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product Calcipressin 1 (or RCAN1) in disease

被引：98

作者：

Harris, CD ^{[1
]}

Ermak, G ^{[1
]}

Davies, KJA ^{[1
]}

机构：

[1] Univ So Calif, Ethel Percy Andrus Gerontol Ctr, Los Angeles, CA 90089 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2005年 / 62卷 / 21期

关键词：

Down syndrome; Alzheimer's disease; cardiac hypertrophy; calcineurin; calcipressin; 1; MCIP1; DSCR1; Adapt78; RCAN1;

D O I：

10.1007/s00018-005-5085-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The DSCR1 (Adapt78) gene(1) is transiently induced by stresses to temporarily protect cells against further potentially lethal challenges. However, chronic expression of the DSCR1 (Adapt78) gene has now been implicated in several pathological conditions including Alzheimer's disease, Down syndrome and cardiac hypertrophy. Calcipressin 1 has been shown to function through direct binding and inhibition of the serine threonine protein phosphatase Calcineurin. Pharmacological inhibition of calcineurin, by the immunosuppressive drugs cyclosporin A and FK506, affects a wide variety of diseases. It is, therefore, likely that this endogenous calcineurin inhibitor, calcipressin 1, may also play a role in a variety of human diseases.

引用

页码：2477 / 2486

页数：10

共 90 条

[1] Localization of calcineurin/NFAT in human skin and psoriasis and inhibition of calcineurin/NFAT activation in human keratinocytes by cyclosporin A
Al-Daraji, WI
Grant, KR
Ryan, K
Saxton, A
Reynolds, NJ
[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2002, 118 (05) : 779 - 788
[2] High level calcineurin activity predisposes neuronal cells to apoptosis
Asai, A
Qiu, JH
Narita, Y
Chi, S
Saito, N
Shinoura, N
Hamada, H
Kuchino, Y
Kirino, T
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (48) : 34450 - 34458
[3] A 50-year retrospective: Cell-mediated immunity and the major histocompatibility complex
Bach, FH
[J]. TRANSPLANTATION PROCEEDINGS, 1999, 31 (1-2) : 16 - 17
[4] Mitochondria to nucleus stress signaling:: a distinctive mechanism of NFκB/Rel activation through calcineurin-mediated inactivation of IκBβ
Biswas, G
Anandatheerthavarada, HK
Zaidi, M
Avadhani, NG
[J]. JOURNAL OF CELL BIOLOGY, 2003, 161 (03) : 507 - 519
[5] Bochelen D, 1999, J PHARMACOL EXP THER, V288, P653
[6] Impaired cardiac hypertrophic response in calcineurin Aβ-deficient mice
Bueno, OF
Wilkins, BJ
Tymitz, KM
Glascock, BJ
Kimball, TF
Lorenz, JN
Molkentin, JD
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (07) : 4586 - 4591
[7] Butcher SP, 1997, J NEUROSCI, V17, P6939
[8] Dscr1, a novel endogenous inhibitor of calcineurin signaling, is expressed in the primitive ventricle of the heart and during neurogenesis
Casas, C
Martínez, S
Pritchard, MA
Fuentes, JJ
Nadal, M
Guimerà, J
Arbonés, M
Flórez, J
Soriano, E
Estivill, X
Alcántara, S
[J]. MECHANISMS OF DEVELOPMENT, 2001, 101 (1-2) : 289 - 292
[9] Alzheimer amyloid β-peptide inhibits the late phase of long-term potentiation through calcineurin-dependent mechanisms in the hippocampal dentate gyrus
Chen, QS
Wei, WZ
Shimahara, T
Xie, CW
[J]. NEUROBIOLOGY OF LEARNING AND MEMORY, 2002, 77 (03) : 354 - 371
[10] A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type
Chin, ER
Olson, EN
Richardson, JA
Yano, Q
Humphries, C
Shelton, JM
Wu, H
Zhu, WG
Bassel-Duby, R
Williams, RS
[J]. GENES & DEVELOPMENT, 1998, 12 (16) : 2499 - 2509

← 1 2 3 4 5 6 7 8 9 →