Experimental analysis of eosinophil-associated gastrointestinal diseases

被引：17

作者：

Hogan, Simon P. ^{[1
]}

Foster, Paul S. ^{[1
]}

Rothenberg, Marc E. ^{[2
]}

机构：

[1] Australian Natl Univ, John Curtin Sch Med Res, Div Biochem & Mol Biol, GPO Box 4, Canberra, ACT 0200, Australia

[2] Childrens Hosp Med Ctr, Dept Pediat, Div Allergy & Immunol, Cincinnati, OH USA

来源：

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY | 2002年 / 2卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1097/00130832-200206000-00014

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Eosinophil infiltration into the gastrointestinal tract occurs in a wide range of diseases. However, the underlying cellular and molecular mechanisms involved in eosinophil migration and the role of eosinophils in disease pathogenesis are largely unknown. Recent studies using experimental models of eosinophil-associated gastrointestinal allergy have revealed differential roles for IL-5 and eotaxin in the modulation of eosinophil accumulation into various regions of the gastrointestinal tract. Furthermore, such studies have revealed a possible role for eosinophils in the pathogenesis of gastrointestinal disorders. The present review describes the clinical manifestations of various eosinophil-associated gastrointestinal disorders and the current understanding of the role of IL-5 and eotaxin in the allergic inflammatory response, and the participation of the eosinophilic granulocyte in the expression of disease. (C) 2002 Lippincott Williams & Wilkins.

引用

页码：239 / 248

页数：10

共 102 条

[1] THE ROLE OF ADHESION MOLECULES IN HUMAN EOSINOPHIL AND BASOPHIL RECRUITMENT [J].

BOCHNER, BS ;

SCHLEIMER, RP .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1994, 94 (03) :427-438

[2]

BOCHNER BS, 1995, J IMMUNOL, V154, P799

[3] INTRAEPITHELIAL EOSINOPHILS IN ENDOSCOPIC BIOPSIES OF ADULTS WITH REFLUX ESOPHAGITIS [J].

BROWN, LF ;

GOLDMAN, H ;

ANTONIOLI, DA .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1984, 8 (12) :899-905

[4] Milk-induced reflux in infants less than one year of age [J].

Cavataio, F ;

Carroccio, A ;

Iacono, G .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2000, 30 :S36-S44

[5] EOSINOPHILIC GASTROENTERITIS - COMPLEX DISEASE ENTITY [J].

CELLO, JP .

AMERICAN JOURNAL OF MEDICINE, 1979, 67 (06) :1097-1104

[6] Salivary, gut, vaginal and nasal antibody responses after oral immunization with biodegradable microparticles [J].

Challacombe, SJ ;

Rahman, D ;

OHagan, DT .

VACCINE, 1997, 15 (02) :169-175

[7] PROSPECTIVE-STUDY OF COLITIS IN INFANCY AND EARLY-CHILDHOOD [J].

CHONG, SKF ;

BLACKSHAW, AJ ;

MORSON, BC ;

WILLIAMS, CB ;

WALKERSMITH, JA .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 1986, 5 (03) :352-358

[8] Deposition of eosinophil-granule major basic protein and expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in the mucosa of the small intestine in infants with cow's milk-sensitive enteropathy [J].

Chung, HL ;

Hwang, JB ;

Kwon, YD ;

Park, MH ;

Shin, WJ ;

Park, JB .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1999, 103 (06) :1195-1201

[9] Activated eosinophils in inflammatory bowel disease: Do they matter? [J].

Desreumaux, P ;

Nutten, S ;

Colombel, JF .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 1999, 94 (12) :3396-3398

[10] AXONAL NECROSIS OF ENTERIC AUTONOMIC NERVES IN CONTINENT ILEAL POUCHES - POSSIBLE IMPLICATIONS FOR PATHOGENESIS OF CROHNS-DISEASE [J].

DVORAK, AM ;

ONDERDONK, AB ;

MCLEOD, RS ;

MONAHANEARLEY, RA ;

CULLEN, J ;

ANTONIOLI, DA ;

BLAIR, JE ;

MORGAN, ES ;

CISNEROS, RL ;

ESTRELLA, P ;

COHEN, Z ;

SILEN, W .

ANNALS OF SURGERY, 1993, 217 (03) :260-271

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