Experimental analysis of eosinophil-associated gastrointestinal diseases

被引：17

作者：

Hogan, Simon P. ^{[1
]}

Foster, Paul S. ^{[1
]}

Rothenberg, Marc E. ^{[2
]}

机构：

[1] Australian Natl Univ, John Curtin Sch Med Res, Div Biochem & Mol Biol, GPO Box 4, Canberra, ACT 0200, Australia

[2] Childrens Hosp Med Ctr, Dept Pediat, Div Allergy & Immunol, Cincinnati, OH USA

来源：

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY | 2002年 / 2卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1097/00130832-200206000-00014

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Eosinophil infiltration into the gastrointestinal tract occurs in a wide range of diseases. However, the underlying cellular and molecular mechanisms involved in eosinophil migration and the role of eosinophils in disease pathogenesis are largely unknown. Recent studies using experimental models of eosinophil-associated gastrointestinal allergy have revealed differential roles for IL-5 and eotaxin in the modulation of eosinophil accumulation into various regions of the gastrointestinal tract. Furthermore, such studies have revealed a possible role for eosinophils in the pathogenesis of gastrointestinal disorders. The present review describes the clinical manifestations of various eosinophil-associated gastrointestinal disorders and the current understanding of the role of IL-5 and eotaxin in the allergic inflammatory response, and the participation of the eosinophilic granulocyte in the expression of disease. (C) 2002 Lippincott Williams & Wilkins.

引用

页码：239 / 248

页数：10

共 102 条

[91]

TORPIER G, 1988, CLIN EXP IMMUNOL, V74, P404

[92]

VENGE P, 1980, EOSINOPHIL HLTH DIS, P1131

[93] THE EOSINOPHIL IN INFLAMMATORY BOWEL-DISEASE [J].