Developmental pathways in colon cancer Crosstalk between WNT, BMP, Hedgehog and Notch

被引：136

作者：

Bertrand, Fred E. ^{[1
]}

Angus, C. William ^{[1
]}

Partis, William J. ^{[1
]}

Sigounas, George ^{[1
]}

机构：

[1] E Carolina Univ, Brody Sch Med, Dept Oncol, Div Canc Biol, Greenville, NC 27858 USA

来源：

CELL CYCLE | 2012年 / 11卷 / 23期

关键词：

colon; stem cell; notch; BMP; WNT; hedgehog; tumor; cancer; target therapy; BETA-CATENIN; SIGNALING PATHWAYS; COLORECTAL-CANCER; STEM-CELLS; TUMOR-SUPPRESSOR; GROWTH-FACTOR; TGF-BETA; INTESTINAL HOMEOSTASIS; INITIATING CELLS; TARGET GENES;

D O I：

10.4161/cc.22134

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A hallmark of cancer is reactivation/alteration of pathways that control cellular differentiation during developmental processes. Evidence indicates that WNT, Notch, BMP and Hedgehog pathways have a role in normal epithelial cell differentiation, and that alterations in these pathways accompany establishment of the tumorigenic state. Interestingly, there is recent evidence that these pathways are intertwined at the molecular level, and these nodes of intersection may provide opportunities for effective targeted therapies. This review will highlight the role of the WNT, Notch, BMP and Hedgehog pathways in colon cancer.

引用

页码：4344 / 4351

页数：8

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