Leptin, neuropeptide Y, and peptide YY in long-term recovered eating disorder patients

被引：67

作者：

Gendall, KA ^{[1
]}

Kaye, WH ^{[1
]}

Altemus, M ^{[1
]}

McConaha, CW ^{[1
]}

La Via, MC ^{[1
]}

机构：

[1] Univ Pittsburgh, Med Ctr, Ctr Overcoming Problem Eating, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USA

来源：

BIOLOGICAL PSYCHIATRY | 1999年 / 46卷 / 02期

关键词：

leptin; neuropeptide Y; peptide YY; recovered eating disorders;

D O I：

10.1016/S0006-3223(98)00292-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Disturbances of leptin, neuropeptide Y (NPY), and peptide YY (PYY) have been found in women who are ill with anorexia or bulimia nervosa. it is not certain whether peptide disturbances are cause or consequence of eating disorders. Methods: Plasma leptin and cerebrospinal fluid leptin, NPY, and PW concentrations were measured ill women who were recovered from anorexia or bulimia nervosa to determine, whether alterations persisted after recovery. Results: NPY, PYY, and leptin concentrations were similar across all diagnostic groups. Conclusions: Alterations in NPY, PYY, and serum leptin concentrations are probably secondary to pathological eating behaviors. Alterations of these peptides are unlikely to be trait-related disturbances that contribute to the etiology of eating disorders. (C) 1999 Society of Biological Psychiatry.

引用

页码：292 / 299

页数：8