Association studies of the BDNF and the NTRK2 gene polymorphisms with prophylactic lithium response in bipolar patients

被引：60

作者：

Dmitrzak-Weglarz, Monika ^{[1
]}

Rybakowski, Janusz K. ^{[2
]}

Suwalska, Aleksandra

Skibinska, Maria ^{[1
]}

Leszczynska-Rodziewicz, Anna ^{[1
]}

Szczepankiewicz, Aleksandra ^{[1
]}

Hauser, Joanna ^{[1
]}

机构：

[1] Univ Med Sci, Dept Psychiat, Lab Psychiat Genet, PL-60572 Poznan, Poland

[2] Poznan Univ Med Sci, Dept Adult Psychiat, Poznan, Poland

来源：

PHARMACOGENOMICS | 2008年 / 9卷 / 11期

关键词：

BDNF; brain-derived neurotrophin factor; bipolar disorder; lithium prophylaxis; neurotrophic tyrosine receptor kinase; NTRK2; type; 2; pharmacogenetics;

D O I：

10.2217/14622416.9.11.1595

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The neuroplasticity hypothesis of bipolar disorder indicates that the BDNF/Trk signaling pathway is associated with the pathogenesis of this illness and treatment with mood stabilizers, such as lithium. This paper describes a relationship between response to lithium prophylaxis and polymorphisms of two functionally connected genes: BDNF and NTRK2, in bipolar illness. Analyses of four SNPs of the BDNF gene (rs2030324, rs988748, rs6265 [Val66Met] and rs2203877) and three of the NTRK2 gene (rs1187326, rs2289656, rs1187327) were performed in the 108 bipolar patients, classified as excellent responders (23%), partial responders (51%) and nonresponders (26%) to lithium. An association of C/G (rs988748) and G/A (rs6265) polymorphisms of the BDNF gene with a degree of prophylactic lithium response were found. No association with lithium response was revealed with the polymorphism of NTRK2 gene, neither with interaction of BDNF and NTRK2 genes.

引用

页码：1595 / 1603

页数：9

共 45 条

[1] Association study of neurotrophic tyrosine kinase receptor type 2 (NTRK2) and childhood-onset mood disorders [J].

Adams, JH ;

Wigg, KG ;

King, N ;

Burcescu, I ;

Vetró, A ;

Kiss, E ;

Baji, I ;

George, CJ ;

Kennedy, JL ;

Kovacs, M ;

Barr, CL .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2005, 132B (01) :90-95

[2] Significant association of BDNF haplotypes in European-American male smokers but not in European-American female or African-American smokers [J].

Beuten, J ;

Ma, JZ ;

Payne, TJ ;

Dupont, RT ;

Quezada, P ;

Huang, WH ;

Crews, KA ;

Li, MD .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2005, 139B (01) :73-80

[3] Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes [J].

Cunha, Angelo B. M. ;

Frey, Benicio N. ;

Andreazza, Ana C. ;

Goi, Julia D. ;

Rosa, Adriane R. ;

Goncalves, Carlos A. ;

Santin, Aida ;

Kapczinski, Flavio .

NEUROSCIENCE LETTERS, 2006, 398 (03) :215-219

[4] BDNF variability in opioid addicts and response to methadone treatment:: preliminary findings [J].

de Cid, R. ;

Fonseca, F. ;

Gratacos, M. ;

Gutierrez, F. ;

Martin-Santos, R. ;

Estivill, X. ;

Torrens, M. .

GENES BRAIN AND BEHAVIOR, 2008, 7 (05) :515-522

[5] The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function [J].

Egan, MF ;

Kojima, M ;

Callicott, JH ;

Goldberg, TE ;

Kolachana, BS ;

Bertolino, A ;

Zaitsev, E ;

Gold, B ;

Goldman, D ;

Dean, M ;

Lu, B ;

Weinberger, DR .

CELL, 2003, 112 (02) :257-269

[6] Linkage disequilibrium of the brain-derived neurotrophic factor Val66Met polymorphism in children with a prepubertal and early adolescent bipolar disorder phenotype [J].

Geller, B ;

Badner, JA ;

Tillman, R ;

Christian, SL ;

Bolhofner, K ;

Cook, EH .

AMERICAN JOURNAL OF PSYCHIATRY, 2004, 161 (09) :1698-1700

[7] Glycogen synthase kinase-3: a putative molecular target for lithium mimetic drugs [J].

Gould, TD ;

Manji, HK .

NEUROPSYCHOPHARMACOLOGY, 2005, 30 (07) :1223-1237

[8] Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder - Case-control study of over 3000 individuals from the UK [J].

Green, EK ;

Raybould, R ;

MacGregor, S ;

Hyde, S ;

Young, AH ;

O'Donovan, MC ;

Owen, MJ ;

Kirov, G ;

Jones, L ;

Jones, I ;

Craddock, N .

BRITISH JOURNAL OF PSYCHIATRY, 2006, 188 :21-25

[9]

Grof P., 1999, LITHIUM, V50, P36

[10] USE OF LITHIUM-SALTS IN AFFECTIVE-DISORDERS [J].

HARTIGAN, GP .

BRITISH JOURNAL OF PSYCHIATRY, 1963, 109 (463) :810-&

← 1 2 3 4 5 →