Elementary arithmetic operations by enzymes: A model for metabolic pathway based computing

被引：169

作者：

Baron, R ^{[1
]}

Lioubashevski, O ^{[1
]}

Katz, E ^{[1
]}

Niazov, T ^{[1
]}

Willner, I ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Inst Chem, IL-91904 Jerusalem, Israel

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 10期

关键词：

enzymes; logic gates; metabolism; redox chemistry;

D O I：

10.1002/anie.200503314

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Physio-logical: A system of four enzymes, horseradish peroxidase, glucose dehydrogenase, glucose oxidase, and catalase, operate in parallel in the presence of NADH and NAD+ to yield AND and XOR gates (see picture). Glucose and H2O2 act as the inputs, and the absorbance that follows the production of gluconic acid or NADH provide the outputs of the AND and XOR gates, respectively. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1572 / 1576

页数：5

共 31 条

[1] Molecule-based photonically switched half-adder
Andréasson, J
Kodis, G
Terazono, Y
Liddell, PA
Bandyopadhyay, S
Mitchell, RH
Moore, TA
Moore, AL
Gust, D
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (49) : 15926 - 15927
[2] COMPUTATIONAL FUNCTIONS IN BIOCHEMICAL REACTION NETWORKS
ARKIN, A
ROSS, J
[J]. BIOPHYSICAL JOURNAL, 1994, 67 (02) : 560 - 578
[3] Boolean logic functions of a synthetic peptide network
Ashkenasy, G
Ghadiri, MR
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (36) : 11140 - 11141
[4] Programmable and autonomous computing machine made of biomolecules
Benenson, Y
Paz-Elizur, T
Adar, R
Keinan, E
Livneh, Z
Shapiro, E
[J]. NATURE, 2001, 414 (6862) : 430 - 434
[5] An autonomous molecular computer for logical control of gene expression
Benenson, Y
Gil, B
Ben-Dor, U
Adar, R
Shapiro, E
[J]. NATURE, 2004, 429 (6990) : 423 - 429
[6] PROTEIN MOLECULES AS COMPUTATIONAL ELEMENTS IN LIVING CELLS
BRAY, D
[J]. NATURE, 1995, 376 (6538) : 307 - 312
[7] Electronically configurable molecular-based logic gates
Collier, CP
Wong, EW
Belohradsky, M
Raymo, FM
Stoddart, JF
Kuekes, PJ
Williams, RS
Heath, JR
[J]. SCIENCE, 1999, 285 (5426) : 391 - 394
[8] Logic operations at the molecular level. An XOR gate based on a molecular machine
Credi, A
Balzani, V
Langford, SJ
Stoddart, JF
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (11) : 2679 - 2681
[9] A MOLECULAR PHOTOIONIC AND GATE BASED ON FLUORESCENT SIGNALING
DE SILVA, AP
GUNARATNE, HQN
MCCOY, CP
[J]. NATURE, 1993, 364 (6432) : 42 - 44
[10] Implementation of a multifunctional logic gate based on folding/unfolding transitions of a protein
Deonarine, AS
Clark, SM
Konermann, L
[J]. FUTURE GENERATION COMPUTER SYSTEMS, 2003, 19 (01) : 87 - 97

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