Artemisinin resistance in Plasmodium falciparum: what is it really?

被引：39

作者：

Ferreira, Pedro Eduardo ^{[1
,2
,3
]}

Culleton, Richard ^{[4
]}

Gil, Jose Pedro ^{[5
,6
]}

Meshnick, Steven Richard ^{[7
]}

机构：

[1] Nagasaki Univ, Inst Trop Med NEKKEN, Dept Protozool, Nagasaki 852, Japan

[2] Univ Algarve, Ctr Mol & Struct Biomed, Inst Biotechnol & Bioengn, Faro, Portugal

[3] Karolinska Inst, Dept Microbiol Tumour & Cell Biol, Stockholm, Sweden

[4] Nagasaki Univ, Inst Trop Med NEKKEN, Malaria Unit, Nagasaki 852, Japan

[5] Karolinska Inst, Dept Physiol & Pharmacol, Drug Resistance Unit, Div Pharmacogenet, Stockholm, Sweden

[6] Binghamton Univ, Harpur Coll Arts & Sci, Dept Biol Sci, New York, NY USA

[7] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA

来源：

TRENDS IN PARASITOLOGY | 2013年 / 29卷 / 07期

关键词：

ANTIMALARIAL-DRUG RESISTANCE; MALARIA; COMBINATION;

D O I：

10.1016/j.pt.2013.05.002

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程]; 100103 [病原生物学];

摘要：

Until very recently, artemisinin and its derivatives were the only commercially available antimalarial drugs for which there was no reported parasite resistance. Artemisinin combination therapies (ACTs) are currently relied upon for effective malaria treatment in most regions of the world in which the disease is endemic, and their continuing efficacy is crucial if control and elimination programmes are to succeed. The loss of effectiveness of artemisinin and its derivatives to drug resistance would constitute a major disaster in the fight against malaria. To properly assess the danger posed by artemisinin resistance, and therefore enable appropriate and proportionate responses, definitions of 'artemisinin resistance' and 'ACT resistance', at both the clinical and parasitological levels, are needed.

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收藏

页码：318 / 320

页数：3

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