Role of enhanced noradrenergic transmission within the ventral bed nucleus of the stria terminalis in visceral pain-induced aversion in rats

被引:31
作者
Deyama, Satoshi [1 ,2 ]
Katayama, Takahiro [1 ]
Kondoh, Naoto [1 ]
Nakagawa, Takayuki [2 ]
Kaneko, Shuji [2 ]
Yamaguchi, Taku [3 ]
Yoshioka, Mitsuhiro [3 ]
Minami, Masabumi [1 ]
机构
[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Dept Pharmacol, Kita Ku, Sapporo, Hokkaido 0600812, Japan
[2] Kyoto Univ, Grad Sch Pharmaceut Sci, Dept Mol Pharmacol, Kyoto 6068501, Japan
[3] Hokkaido Univ, Grad Sch Med, Dept Neuropharmacol, Sapporo, Hokkaido 0608638, Japan
基金
日本学术振兴会;
关键词
Acetic acid; beta-Adrenoceptor; Bed nucleus of the stria terminalis; Conditioned place aversion; Emotion; Extended amygdala; Noradrenaline; Visceral pain; NEGATIVE AFFECTIVE COMPONENT; SPINAL-CORD; NORADRENALINE; INVOLVEMENT; NEURONS; PATHWAY; ACTIVATION; RESPONSES; AMYGDALA; TRACT;
D O I
10.1016/j.bbr.2008.08.024
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Pain is an unpleasant sensory and emotional experience. We demonstrated the crucial role of the bed nucleus of the stria terminalis (BNST) in the negative affective component of somatic and visceral pain induced by intraplantar formalin and intraperitoneal acetic acid injections, respectively, in rats. Recently, we reported the involvement of enhanced noradrenergic transmission via beta-adrenoceptors within the ventral BNST (vBNST) in formalin-induced aversion. Here, we examined the role of intra-vBNST noradrenergic transmission in the negative affective component of visceral pain induced by intraperitoneal acetic acid injection. In vivo microdialysis showed that extracellular noradrenaline levels within the vBNST significantly increased after intraperitoneal acetic acid injection. Using a conditioned place aversion (CPA) test, we found that intra-vBNST injection of timolol, a beta-adrenoceptor antagonist, dose-dependently attenuated the acetic acid-induced CPA without reducing nociceptive behaviors. These results suggest that enhanced noradrenergic transmission via beta-adrenoceptors within the vBNST plays a pivotal role in the negative affective, but not sensory, component of visceral pain. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码:279 / 283
页数:5
相关论文
共 24 条
[1]   THE PARABRACHIAL AREA - ELECTROPHYSIOLOGICAL EVIDENCE FOR AN INVOLVEMENT IN VISCERAL NOCICEPTIVE PROCESSES [J].
BERNARD, JF ;
HUANG, GF ;
BESSON, JM .
JOURNAL OF NEUROPHYSIOLOGY, 1994, 71 (05) :1646-1660
[2]  
Bernard JF, 1996, PROG BRAIN RES, V107, P243
[3]   Basic and clinical aspects of visceral sensation: transmission in the CNS [J].
Bielefeldt, K ;
Christianson, JA ;
Davis, BM .
NEUROGASTROENTEROLOGY AND MOTILITY, 2005, 17 (04) :488-499
[4]  
Bielefeldt K., 2006, Wall and Melzack's Textbook of Pain, V5th edn, P721
[5]   Modulatory effects of norepinephrine in the lateral bed nucleus of the stria terminalis on behavioral and neuroendocrine responses to acute stress [J].
Cecchi, M ;
Khoshbouei, H ;
Javors, M ;
Morilak, DA .
NEUROSCIENCE, 2002, 112 (01) :13-21
[6]   Visceral pain [J].
Cervero, F ;
Laird, JMA .
LANCET, 1999, 353 (9170) :2145-2148
[7]   Noradrenaline in the ventral forebrain is critical for opiate withdrawal-induced aversion [J].
Delfs, JM ;
Zhu, Y ;
Druhan, JP ;
Aston-Jones, G .
NATURE, 2000, 403 (6768) :430-434
[8]   Activation of the β-adrenoceptor-protein kinase A signaling pathway within the ventral bed nucleus of the stria terminalis mediates the negative affective component of pain in rats [J].
Deyama, Satoshi ;
Katayama, Takahiro ;
Ohno, Atsushi ;
Nakagawa, Takayuki ;
Kaneko, Shuji ;
Yamaguchi, Taku ;
Yoshioka, Mitsuhiro ;
Minami, Masabumi .
JOURNAL OF NEUROSCIENCE, 2008, 28 (31) :7728-7736
[9]   Involvement of the bed nucleus of the stria terminalis in the negative affective component of visceral and somatic pain in rats [J].
Deyama, Satoshi ;
Nakagawa, Takayuki ;
Kaneko, Shuji ;
Uehara, Takashi ;
Minami, Masabumi .
BEHAVIOURAL BRAIN RESEARCH, 2007, 176 (02) :367-371
[10]   Noradrenaline triggers GABAA inhibition of bed nucleus of the stria terminalis neurons projecting to the ventral tegmental area [J].
Dumont, ÉC ;
Williams, JT .
JOURNAL OF NEUROSCIENCE, 2004, 24 (38) :8198-8204