Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice

被引：503

作者：

Peek, Clara Bien ^{[1
,2
]}

Nati, Alison H. Affi ^{[1
,2
]}

Ramsey, Kathryn Moynihan ^{[1
,2
]}

Kuo, Hsin-Yu ^{[3
,4
]}

Yu, Wei ^{[5
,6
]}

Sena, Laura A. ^{[7
,8
]}

Ilkayeva, Olga ^{[9
,10
]}

Marcheva, Biliana ^{[1
,2
]}

Kobayashi, Yumiko ^{[1
,2
]}

Omura, Chiaki ^{[1
,2
]}

Levine, Daniel C. ^{[1
,2
]}

Bacsik, David J. ^{[1
,2
]}

Gius, David ^{[11
]}

Newgard, Christopher B. ^{[9
,10
]}

Goetzman, Eric ^{[12
]}

Chandel, Navdeep S. ^{[7
,8
]}

Denu, John M. ^{[5
,6
]}

Mrksich, Milan ^{[3
,4
]}

Bass, Joseph ^{[1
,2
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Endocrinol Metab & Mol Med, Chicago, IL 60611 USA

[2] Northwestern Univ, Dept Neurobiol, Evanston, IL 60208 USA

[3] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

[4] Northwestern Univ, Howard Hughes Med Inst, Evanston, IL 60208 USA

[5] Univ Wisconsin, Dept Biomol Chem, Madison, WI 53715 USA

[6] Univ Wisconsin, Wisconsin Inst Discovery, Madison, WI 53715 USA

[7] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Pulm & Crit Care Med, Chicago, IL 60611 USA

[8] Northwestern Univ, Feinberg Sch Med, Dept Cell & Mol Biol, Chicago, IL 60611 USA

[9] Duke Univ, Med Ctr, Sarah W Stedman Nutr & Metab Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27705 USA

[10] Duke Univ, Med Ctr, Sarah W Stedman Nutr & Metab Ctr, Dept Med, Durham, NC 27705 USA

[11] Northwestern Univ, Feinberg Sch Med, Dept Radiat Oncol, Chicago, IL 60611 USA

[12] Univ Pittsburgh, Sch Med, Childrens Hosp Pittsburgh, Dept Pediat, Pittsburgh, PA 15224 USA

来源：

SCIENCE | 2013年 / 342卷 / 6158期

关键词：

FATTY-ACID OXIDATION; GENE-EXPRESSION; NICOTINAMIDE; PATHWAYS; TISSUE; ACETYLATION; PROMOTES; GLUCOSE; MOUSE; CELLS;

D O I：

10.1126/science.1243417

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Circadian clocks are self-sustained cellular oscillators that synchronize oxidative and reductive cycles in anticipation of the solar cycle. We found that the clock transcription feedback loop produces cycles of nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, adenosine triphosphate production, and mitochondrial respiration through modulation of mitochondrial protein acetylation to synchronize oxidative metabolic pathways with the 24-hour fasting and feeding cycle. Circadian control of the activity of the NAD(+)-dependent deacetylase sirtuin 3 (SIRT3) generated rhythms in the acetylation and activity of oxidative enzymes and respiration in isolated mitochondria, and NAD(+) supplementation restored protein deacetylation and enhanced oxygen consumption in circadian mutant mice. Thus, circadian control of NAD(+) bioavailability modulates mitochondrial oxidative function and organismal metabolism across the daily cycles of fasting and feeding.

引用

页码：591 / +

页数：9

共 42 条

[31] Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors [J].

Rutter, J ;

Reick, M ;

Wu, LC ;

McKnight, SL .

SCIENCE, 2001, 293 (5529) :510-514

[32] SIRT3 Deacetylates Mitochondrial 3-Hydroxy-3-Methylglutaryl CoA Synthase 2 and Regulates Ketone Body Production [J].

Shimazu, Tadahiro ;

Hirschey, Matthew D. ;

Hua, Lan ;

Dittenhafer-Reed, Kristin E. ;

Schwer, Bjoern ;

Lombard, David B. ;

Li, Yu ;

Bunkenborg, Jakob ;

Alt, Frederick W. ;

Denu, John M. ;

Jacobson, Matthew P. ;

Verdin, Eric .

CELL METABOLISM, 2010, 12 (06) :654-661

[33] Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction [J].

Someya, Shinichi ;

Yu, Wei ;

Hallows, William C. ;

Xu, Jinze ;

Vann, James M. ;

Leeuwenburgh, Christiaan ;

Tanokura, Masaru ;

Denu, John M. ;

Prolla, Tomas A. .

CELL, 2010, 143 (05) :802-812

[34] Extensive and divergent circadian gene expression in liver and heart [J].

Storch, KF ;

Lipan, O ;

Leykin, I ;

Viswanathan, N ;

Davis, FC ;

Wong, WH ;

Weitz, CJ .

NATURE, 2002, 417 (6884) :78-83

[35] Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress [J].

Tao, Randa ;

Coleman, Mitchell C. ;

Pennington, J. Daniel ;

Ozden, Ozkan ;

Park, Seong-Hoon ;

Jiang, Haiyan ;

Kim, Hyun-Seok ;

Flynn, Charles Robb ;

Hill, Salisha ;

McDonald, W. Hayes ;

Olivier, Alicia K. ;

Spitz, Douglas R. ;

Gius, David .

MOLECULAR CELL, 2010, 40 (06) :893-904

[36] Obesity and metabolic syndrome in circadian Clock mutant mice [J].

Turek, FW ;

Joshu, C ;

Kohsaka, A ;

Lin, E ;

Ivanova, G ;

McDearmon, E ;

Laposky, A ;

Losee-Olson, S ;

Easton, A ;

Jensen, DR ;

Eckel, RH ;

Takahashi, JS ;

Bass, J .

SCIENCE, 2005, 308 (5724) :1043-1045

[37] ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease [J].

Wu, JY ;

Kao, HJ ;

Li, SC ;

Stevens, R ;

Hillman, S ;

Millington, D ;

Chen, YT .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (03) :434-440

[38] Resonating circadian clocks enhance fitness in cyanobacteria [J].

Yan, OY ;

Andersson, CR ;

Kondo, T ;

Golden, SS ;

Johnson, CH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (15) :8660-8664

[39] Nuclear receptor expression links the circadian clock to metabolism [J].

Yang, Xiaoyong ;

Downes, Michael ;

Yu, Ruth T. ;

Bookout, Angie L. ;

He, Weimin ;

Straume, Marty ;

Mangelsdorf, David J. ;

Evans, Ronald M. .

CELL, 2006, 126 (04) :801-810

[40] Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice [J].

Yoshino, Jun ;

Mills, Kathryn F. ;

Yoon, Myeong Jin ;

Imai, Shin-ichiro .

CELL METABOLISM, 2011, 14 (04) :528-536

← 1 2 3 4 5 →