The diagnostic value of hepatocyte paraffin antibody 1 in differentiating hepatocellular neoplasms from nonhepatic tumors: A review

被引：41

作者：

Lamps, LW

Folpe, AL

机构：

[1] Univ Arkansas Med Sci, Dept Pathol, Little Rock, AR 72205 USA

[2] Emory Univ, Sch Med, Atlanta, GA USA

来源：

ADVANCES IN ANATOMIC PATHOLOGY | 2003年 / 10卷 / 01期

关键词：

hepatocyte paraffin-1; hepatocellular carcinoma; hepatoblastoma; cholangiocarcinoma; adenocarcinoma; immunohistochemistry;

D O I：

10.1097/00125480-200301000-00004

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Hepatocyte paraffin-1 (HepPar-1) is a recently developed monoclonal antibody that appears to identify an antigen unique to hepatocellular mitochondria. This article reviews the use of this new antibody in the differential diagnosis of primary hepatocellular neoplasms, cholangiocarcinomas, and carcinomas metastatic to the liver. Hepatocyte paraffin-1 appears to be the most sensitive and specific positive marker of hepatocellular differentiation, but like any immunohistochemical marker, should be interpreted only in the context of the overall clinicopathologic picture and as part of a panel of antibodies.

引用

页码：39 / 43

页数：5

共 25 条

[1] Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: A survey of 435 cases [J].