MRP1-transfected cells do not show increased resistance against oxidative stress

被引：9

作者：

Balcerczyk, A ^{[1
]}

Rychlik, B

Kruszewski, M

Burchell, B

Bartosz, G

机构：

[1] Univ Lodz, Dept Mol Biophys, PL-90237 Lodz, Poland

[2] Inst Nucl Chem & Technol, Dept Radiobiol & Hlth Protect, PL-03195 Warsaw, Poland

[3] Univ Dundee, Ninewells Hosp & Med Sch, Dept Mol & Cellular Pathobiol, Dundee DD1 9SY, Scotland

[4] Univ Rzeszow, Dept Biochem & Cell Biol, Rzeszow, Poland

来源：

FREE RADICAL RESEARCH | 2003年 / 37卷 / 02期

关键词：

MRP1; multidrug resistance protein; glutathione; oxidative stress;

D O I：

10.1080/1071576021000040989

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sensitivity of V79 Chinese hamster cells and V79 cells transfected with human MRP1 gene to several agents inducing oxidative stress was compared. Cells overexpressing MRP1 did not show increased resistance to tert-butyl hydroperoxide, diamide, paraquat, menadione, dichromate and carmustine as estimated by cell survival and DNA damage assessed by comet assay. These findings suggest that overexpression of MRP1 does not confer increased resistance to oxidative stress.

引用

页码：189 / 195

页数：7

共 35 条

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