Phosphodiesterase 4 inhibitors for the treatment of asthma

被引:18
作者
Karlsson, JA
Aldous, D
机构
[1] Rhone-Poulenc Ltd, Dagenham Essex RM10 7XS, Rainham Road South
关键词
anti-inflammatory; asthma; bronchodilator; emesis; phosphodiesterase; rheumatoid arthritis;
D O I
10.1517/13543776.7.9.989
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
This paper reviews the literature on the modulation of cyclic adenosine 3',5'-monophosphates (cAMP) by inhibition of phosphodiesterase 4 (PDE 4) enzyme. It highlights why PDE 4 is an interesting anti-inflammatory target, particularly for asthma. Focus is given to the selective and non-selective phosphodiesterase inhibitors presently disclosed in the current scientific literature and patent literature up to June of 1996. It reviews the pre-clinical and clinical data available for these inhibitors and discusses the future for development of novel PDE 4 inhibitors.
引用
收藏
页码:989 / 1003
页数:15
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