Studies on the total synthesis of macrolactin A.: A stereoselective synthesis of the C3-C13 and C14-C24 fragments

被引：23

作者：

Li, SK ^{[1
]}

Xu, R ^{[1
]}

Bai, DL ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 18期

基金：

中国国家自然科学基金;

关键词：

macrolactin A; antiviral; stereoselective synthesis; Wittig olefination; sulfone alkylation;

D O I：

10.1016/S0040-4039(00)00412-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthetic studies towards the C-3-C-13 (2) and C-14-C-24 (3) segments of the potent antiviral and antitumor compound macrolactin A (1) are presented. Segment 2 was constructed via a convergent and facile approach, exploiting Wittig olefination to generate the sensitive E,Z-diene moiety. Segment 3 was obtained from the chiral pool derived sulfone 4 via an alpha-alkylation-desulfonation reaction sequence. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3463 / 3466

页数：4

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