Solid phase urea synthesis: An efficient and direct conversion of Fmoc-protected amines to ureas

被引：17

作者：

Chong, PY ^{[1
]}

Petillo, PA ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Roger Adams Lab, Urbana, IL 61801 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 24期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(99)00820-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient "one-pot" conversion of Fmoc-protected amino acids to the ureas in the solid phase is described. This methodology uses MeSiCl3 in the presence of Et3N to cleave Fmoc-protected amines directly to their isocyanates. This transformation has been demonstrated on some Fmoc-protected amino acids. Trapping of the resin-bound isocyanate by the addition of amines generates the desired amino acid ureas in high HPLC purities. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：4501 / 4504

页数：4

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