Vitamin D: criteria for safety and efficacy

被引：94

作者：

Heaney, Robert P. ^{[1
]}

机构：

[1] Creighton Univ, Med Ctr, Omaha, NE 68131 USA

来源：

NUTRITION REVIEWS | 2008年 / 66卷 / 10期

关键词：

calcium absorption; cancer; falls; fractures; hypercalcemia; immune function; insulin response;

D O I：

10.1111/j.1753-4887.2008.00102.x

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The functional status indicator for vitamin D, for both safety and efficacy, is serum 25-hydroxyvitamin D concentration. Efficacy for several health endpoints requires levels of 80 nmol/L or higher. Toxicity occurs at levels of 500 nmol/L or higher. The input needed for efficacy, in addition to typical food and cutaneous inputs, will usually be 1000-2000 IU/day of supplemental cholecalciferol. Toxicity is associated only with excessive supplemental intake (usually well above 20,000 IU/day). (C) 2008 International Life Sciences Institute.

引用

页码：S178 / S181

页数：4

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