Assignment of the NAD-dependent deacetylase sirtuin 5 gene (SIRT5) to human chromosome band 6p23 by in situ hybridization

被引：41

作者：

Mahlknecht, U

Ho, AD

Letzel, S

Voelter-Mahlknecht, S

机构：

[1] Univ Heidelberg, Ctr Med, Dept Hematol Oncol, DE-69120 Heidelberg, Germany

[2] Univ Mainz, Dept Occupat Social & Environm Med, D-6500 Mainz, Germany

来源：

CYTOGENETIC AND GENOME RESEARCH | 2006年 / 112卷 / 3-4期

关键词：

D O I：

10.1159/000089872

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sirtuin 5 ( SIRT5) is a nicotinamide adenine dinucleotide ( NAD +)-dependent deacetylase and belongs to the Silent information regulator 2 ( Sir2) family of sirtuin histone deacetylases ( HDACs), which play a central role in epigenetic gene silencing, DNA repair and recombination, cell-cycle, microtubule organization, and in the regulation of aging. We have isolated and characterized the human SIRT5 genomic sequence, which spans a region of 28,182 bp and which has one single genomic locus. Human SIRT5 consists of eight exons and is found in two isoforms, which encode a 310 aa and a 299 aa protein, respectively. Human SIRT5 is most predominantly expressed in heart muscle cells and in lymphoblasts. Fluorescence in situ hybridization analysis localized the human SIRT5 gene to chromosome 6p23.

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页码：208 / 212

页数：5

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