Anatomical substrates of cognitive and clinical dimensions in first episode schizophrenia

被引：30

作者：

Rigucci, S. ^{[1
]}

Rossi-Espagnet, C. ^{[2
]}

Ferracuti, S. ^{[3
]}

De Carolis, A. ^{[3
]}

Corigliano, V. ^{[1
]}

Carducci, F. ^{[4
]}

Mancinelli, I. ^{[1
]}

Cicone, F. ^{[5
]}

Tatarelli, R. ^{[1
]}

Bozzao, A. ^{[1
]}

Girardi, P. ^{[1
]}

Comparelli, A. ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Unit Psychiat, SantAndrea Hosp,Fac Med & Psychol, Dept Neurosci Mental Hlth & Sensory Organs NeSMOS, I-00189 Rome, Italy

[2] Univ Roma La Sapienza, Unit Neuroradiol, SantAndrea Hosp,Fac Med & Psychol, Dept Neurosci Mental Hlth & Sensory Organs NeSMOS, I-00189 Rome, Italy

[3] Univ Roma La Sapienza, Unit Clin Psychol, SantAndrea Hosp,Fac Med & Psychol, Dept Neurosci Mental Hlth & Sensory Organs NeSMOS, I-00189 Rome, Italy

[4] Univ Roma La Sapienza, Fac Med & Pharm, Dept Physiol, I-00189 Rome, Italy

[5] Univ Roma La Sapienza, Unit Nucl Med, SantAndrea Hosp, Dept Translat Med,Fac Med & Psychol, I-00189 Rome, Italy

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 2013年 / 128卷 / 04期

关键词：

first-episode schizophrenia; Positive and Negative Syndrome Scale; voxel-based morphometry; tract-based spatial statistics; neuropsychological impairment; SYNDROME SCALE PANSS; WHITE-MATTER; SYMPTOMS; GRAY; RECOGNITION; GREY; ABNORMALITIES; MORPHOMETRY; CONSENSUS; DEFICITS;

D O I：

10.1111/acps.12051

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

ObjectiveTo explore gray (GM) and white matter (WM) abnormalities and the relationships with neuropsychopathology in first-episode schizophrenia (FES). MethodNineteen patients with first episode of non-affective psychosis and 18 controls underwent a magnetic resonance voxel-based morphometry. Additionally, WM fractional anisotropy (FA) was calculated. For correlative analysis, symptoms and neuropsychological performances were scored by PANSS and by a comprehensive neuropsychological assessment respectively. ResultsPatients showed significantly decreased volume of left temporal lobe and disarray of all major WM tracts. Disorganized PANSS factor was inversely related to left cerebellar GM volume (corrected P=0.03) and to WM FA of the left cerebellum, inferior fronto-occipital fasciculi (IFOF), and inferior longitudinal fasciculi (corrected P<0.05). PANSS negative factor was inversely related to FA in the IFOF and superior longitudinal fasciculi (corrected P<0.05). Impairment in facial emotion identification showed associations with temporo-occipital GM volume decrease (corrected P=0.003) and WM disarray of superior and middle temporal gyri, anterior thalamic radiation, and superior longitudinal fasciculi (corrected P<0.05). Speed of processing and visual memory correlated with WM abnormalities in fronto-temporal tracts. ConclusionThese results confirm how the structural development of key brain regions is related to neuropsychopathological dysfunction in FES, consistently with a neurodevelopmentally derived misconnection syndrome.

引用

页码：261 / 270

页数：10

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