The role of the cerebellum in schizophrenia

被引:514
作者
Andreasen, Nancy C. [1 ]
Pierson, Ronald [1 ]
机构
[1] Univ Iowa, Dept Psychiat, Roy J & Lucille A Carver Coll Med, Iowa City, IA 52242 USA
关键词
cerebellum; cognition; neuroimaging; schizophrenia;
D O I
10.1016/j.biopsych.2008.01.003
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
For many years the cerebellum has been considered to serve as a coordinator of motor function. Likewise, for many years schizophrenia has been considered to be a disease that primarily affects the cerebrum. This review summarizes recent evidence that both these views must be revised in the light of emerging evidence about cerebellar function and the mechanisms of schizophrenia. Evidence indicating that the cerebellum plays a role in higher cortical functions is summarized. Evidence indicating that cerebellar abnormalities occur in schizophrenia is also reviewed. These suggest interesting directions for future research.
引用
收藏
页码:81 / 88
页数:8
相关论文
共 84 条
[1]   A NEW ROLE FOR THE CEREBELLUM IN COGNITIVE OPERATIONS [J].
AKSHOOMOFF, NA ;
COURCHESNE, E .
BEHAVIORAL NEUROSCIENCE, 1992, 106 (05) :731-738
[2]  
ALBUS J S, 1971, Mathematical Biosciences, V10, P25, DOI 10.1016/0025-5564(71)90051-4
[3]   Attentional activation of the cerebellum independent of motor involvement [J].
Allen, G ;
Buxton, RB ;
Wong, EC ;
Courchesne, E .
SCIENCE, 1997, 275 (5308) :1940-1943
[4]   Differential effects of developmental cerebellar abnormality on cognitive and motor functions in the cerebellum: An fMRI study of autism [J].
Allen, G ;
Courchesne, E .
AMERICAN JOURNAL OF PSYCHIATRY, 2003, 160 (02) :262-273
[5]   Defining the phenotype of schizophrenia: Cognitive dysmetria and its neural mechanisms [J].
Andreasen, NC ;
Nopoulos, P ;
O'Leary, DS ;
Miller, DD ;
Wassink, T ;
Flaum, L .
BIOLOGICAL PSYCHIATRY, 1999, 46 (07) :908-920
[6]   A unitary model of schizophrenia -: Bleuler's "fragmented phrene" as schizencephaly [J].
Andreasen, NC .
ARCHIVES OF GENERAL PSYCHIATRY, 1999, 56 (09) :781-787
[7]   Schizophrenia and cognitive dysmetria: A positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry [J].
Andreasen, NC ;
OLeary, DS ;
Cizadlo, T ;
Arndt, S ;
Rezai, K ;
Ponto, LLB ;
Watkins, GL ;
Hichwa, RD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (18) :9985-9990
[8]   Cognitive dysmetria as an integrative theory of schizophrenia: A dysfunction in cortical subcortical-cerebellar circuitry? [J].
Andreasen, NC ;
Paradiso, S ;
O'Leary, DS .
SCHIZOPHRENIA BULLETIN, 1998, 24 (02) :203-218
[9]   Linking mind and brain in the study of mental illnesses: A project for a scientific psychopathology [J].
Andreasen, NC .
SCIENCE, 1997, 275 (5306) :1586-1593
[10]  
Andreasen NC, 1999, HUM BRAIN MAPP, V8, P226, DOI 10.1002/(SICI)1097-0193(1999)8:4<226::AID-HBM6>3.3.CO