The role of the cerebellum in schizophrenia

被引:514
作者
Andreasen, Nancy C. [1 ]
Pierson, Ronald [1 ]
机构
[1] Univ Iowa, Dept Psychiat, Roy J & Lucille A Carver Coll Med, Iowa City, IA 52242 USA
关键词
cerebellum; cognition; neuroimaging; schizophrenia;
D O I
10.1016/j.biopsych.2008.01.003
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
For many years the cerebellum has been considered to serve as a coordinator of motor function. Likewise, for many years schizophrenia has been considered to be a disease that primarily affects the cerebrum. This review summarizes recent evidence that both these views must be revised in the light of emerging evidence about cerebellar function and the mechanisms of schizophrenia. Evidence indicating that the cerebellum plays a role in higher cortical functions is summarized. Evidence indicating that cerebellar abnormalities occur in schizophrenia is also reviewed. These suggest interesting directions for future research.
引用
收藏
页码:81 / 88
页数:8
相关论文
共 84 条
[81]  
VOLKOW ND, 1992, AM J PSYCHIAT, V149, P686
[82]   Working memory dysfunction in schizophrenia compared to healthy controls and patients with depression:: Evidence from event-related fMRI [J].
Walter, Henrik ;
Vasic, Nenad ;
Hoese, Annett ;
Spitzer, Manfred ;
Wolf, Robert Christian .
NEUROIMAGE, 2007, 35 (04) :1551-1561
[83]  
WEINBERGER DR, 1979, LANCET, V1, P718
[84]   Is schizophrenia a progressive neurodevelopmental disorder? Toward a unitary pathogenetic mechanism [J].
Woods, BT .
AMERICAN JOURNAL OF PSYCHIATRY, 1998, 155 (12) :1661-1670