Secretion of Glucose-Dependent Insulinotropic Polypeptide in Patients With Type 2 Diabetes Systematic review and meta-analysis of clinical studies

被引:132
作者
Calanna, Salvatore [1 ,2 ]
Christensen, Mikkel [1 ]
Holst, Jens J. [1 ,3 ]
Laferrere, Blandine [4 ]
Gluud, Lise L. [1 ]
Vilsboll, Tina [1 ]
Knop, Filip K. [1 ,3 ]
机构
[1] Univ Copenhagen, Gentofte Hosp, Dept Med, Diabet Res Div, Hellerup, Denmark
[2] Univ Catania, Dept Clin & Mol Biomed, Catania, Italy
[3] Univ Copenhagen, Panum Inst, Dept Biomed Sci, Novo Nordisk Fdn,Ctr Basic Metab Res, DK-2200 Copenhagen, Denmark
[4] Columbia Univ Coll Phys & Surg, St Lukes Roosevelt Hosp Ctr, Obes Nutr Res Ctr, New York, NY 10032 USA
关键词
GASTRIC-INHIBITORY POLYPEPTIDE; GLUCAGON-LIKE PEPTIDE-1; ORAL GLUCOSE; BYPASS-SURGERY; GIP SECRETION; WEIGHT-LOSS; MELLITUS; RESPONSES; OBESITY; HORMONES;
D O I
10.2337/dc13-0465
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVETo investigate glucose-dependent insulinotropic polypeptide (GIP) secretion in patients with type 2 diabetes and nondiabetic control subjects during oral glucose or meal tests.RESEARCH DESIGN AND METHODSEligible trials were identified by The Cochrane Library, MEDLINE, Embase, and Web of Science. Data were retrieved and random-effects models for the primary meta-analysis, random-effects meta-regression, and subgroup and regression analyses were applied.RESULTSRandom-effects meta-analysis of GIP responses in 23 trials during 28 different stimulation tests showed that patients with type 2 diabetes (n = 363) exhibited no significant differences (P = not significant) in peak plasma GIP, total area under the curve (tAUC), time-corrected tAUC (tAUC x min(-1)), and time-corrected incremental area under the curve (iAUC x min(-1)) in comparison with nondiabetic control subjects (n = 325) but had lower GIP responses as evaluated from iAUC (weighted mean difference, -648 pmol/L x min; 95% CI, -1,276 to -21). Fixed-effects models meta-analyses confirmed most of the results of the primary meta-analysis but showed iAUC x min(-1) to be reduced and showed tAUC and tAUC x min(-1) to be higher in diabetic patients. Random-effects meta-regression of the primary meta-analysis showed that age (peak GIP, tAUC, iAUC, and iAUC x min(-1)), BMI (tAUC, iAUC, and iAUC x min(-1)), and HbA(1c) (iAUC and iAUC x min(-1)) predicted some of the GIP outcomes. Post hoc subgroup analysis showed a negative influence of age and of HbA(1c) on GIP responses and showed a positive influence of BMI on GIP responses.CONCLUSIONSOur results suggest that patients with type 2 diabetes are characterized by preserved GIP secretion in response to oral glucose and meal tests. They also suggest that high BMI is associated with increased GIP responses but increasing age and HbA(1c) are associated with reduced GIP secretion.
引用
收藏
页码:3346 / 3352
页数:7
相关论文
共 55 条
  • [31] Effect of ageing and diabetes on glucose-dependent insulinotropic polypeptide and dipeptidyl peptidase IV responses to oral glucose
    Meneilly, GS
    Demuth, HU
    McIntosh, CHS
    Pederson, RA
    [J]. DIABETIC MEDICINE, 2000, 17 (05) : 346 - 350
  • [32] Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients
    Muscelli, Elza
    Mari, Andrea
    Casolaro, Arturo
    Camastra, Stefania
    Seghieri, Giuseppe
    Gastaldelli, Antalia
    Holst, Jens J.
    Ferrannini, Ele
    [J]. DIABETES, 2008, 57 (05) : 1340 - 1348
  • [33] Nasteska D, 2012, DIABETOLOGIA, V55, pS80
  • [34] REDUCED INCRETIN EFFECT IN TYPE-2 (NON-INSULIN-DEPENDENT) DIABETES
    NAUCK, M
    STOCKMANN, F
    EBERT, R
    CREUTZFELDT, W
    [J]. DIABETOLOGIA, 1986, 29 (01) : 46 - 52
  • [35] PRESERVED INCRETIN ACTIVITY OF GLUCAGON-LIKE PEPTIDE-1 [7-36 AMIDE] BUT NOT OF SYNTHETIC HUMAN GASTRIC-INHIBITORY POLYPEPTIDE IN PATIENTS WITH TYPE-2 DIABETES-MELLITUS
    NAUCK, MA
    HEIMESAAT, MM
    ORSKOV, C
    HOLST, JJ
    EBERT, R
    CREUTZFELDT, W
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (01) : 301 - 307
  • [36] ADDITIVE INSULINOTROPIC EFFECTS OF EXOGENOUS SYNTHETIC HUMAN GASTRIC-INHIBITORY POLYPEPTIDE AND GLUCAGON-LIKE PEPTIDE-1-(7-36) AMIDE INFUSED AT NEAR-PHYSIOLOGICAL INSULINOTROPIC HORMONE AND GLUCOSE-CONCENTRATIONS
    NAUCK, MA
    BARTELS, E
    ORSKOV, C
    EBERT, R
    CREUTZFELDT, W
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1993, 76 (04) : 912 - 917
  • [37] INCRETIN EFFECTS OF INCREASING GLUCOSE LOADS IN MAN CALCULATED FROM VENOUS INSULIN AND C-PEPTIDE RESPONSES
    NAUCK, MA
    HOMBERGER, E
    SIEGEL, EG
    ALLEN, RC
    EATON, RP
    EBERT, R
    CREUTZFELDT, W
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1986, 63 (02) : 492 - 498
  • [38] OSEI K, 1986, J CLIN ENDOCR METAB, V62, P325, DOI 10.1210/jcem-62-2-325
  • [39] The Influence of Autonomic Dysfunction Associated with Aging and Type 2 Diabetes on Daily Life Activities
    Petrofsky, Jerrold
    Berk, Lee
    Al-Nakhli, Hani
    [J]. EXPERIMENTAL DIABETES RESEARCH, 2012,
  • [40] GASTRIC-INHIBITORY POLYPEPTIDE RESPONSE TO HYPERGLYCEMIA AND HYPOGLYCEMIA IN INSULIN-DEPENDENT DIABETICS
    REYNOLDS, C
    TRONSGARD, N
    GIBBONS, E
    BLIX, PM
    RUBENSTEIN, AH
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1979, 49 (02) : 255 - 261