Mechanisms of deep brain stimulation

被引:210
作者
Benabid, AL [1 ]
Benazzous, A
Pollak, P
机构
[1] CHU A Michallon, Dept Neurosurg, F-38043 Grenoble, France
[2] Univ Grenoble 1, CHU Grenoble, Dept Neurosci, Grenoble, France
关键词
D O I
10.1002/mds.10145
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The mechanism of action of high frequency deep brain stimulation is still unknown. However, in all circumstances and in all target nuclei so far stimulated, the effects mimic those of lesions previously made during thalamotomies, pallidotomies or even subthalamotomies, suggesting an inhibition of at least the neuronal network containing the target, if not of the target itself. On the contrary, fiber bundles are consistently activated at low or high frequencies. The hypothetical mechanisms envisioned should therefore be compatible and even produce these observed effects, to be acceptable as hypotheses. The mechanism could be either one or a combination of several causes: jamming of a feedback loop, activation of inhibitory structures included in a more complex network, blockade of membrane ion channels, deplorisation blockade, synaptic exhaustion, induction of early genes, changes in local blood flow, neuroplasticity, etc. It is probable that some are more involved in the acute effects and others in the long term changes, close to neuroplasticity. It is clear that the understanding of this strange and powerful phenomenon will profit from both clinical observation and well designed animal experiments. (C) 2002 Movement Disorder Society.
引用
收藏
页码:S73 / S74
页数:2
相关论文
共 4 条
[1]   RESPONSES OF SUBSTANTIA-NIGRA PARS RETICULATA AND GLOBUS-PALLIDUS COMPLEX TO HIGH-FREQUENCY STIMULATION OF THE SUBTHALAMIC NUCLEUS IN RATS - ELECTROPHYSIOLOGICAL DATA [J].
BENAZZOUZ, A ;
PIALLAT, B ;
POLLAK, P ;
BENABID, AL .
NEUROSCIENCE LETTERS, 1995, 189 (02) :77-80
[2]   High-frequency stimulation produces a transient blockade of voltage-gated currents in subthalamic neurons [J].
Beurrier, C ;
Bioulac, B ;
Audin, J ;
Hammond, C .
JOURNAL OF NEUROPHYSIOLOGY, 2001, 85 (04) :1351-1356
[3]   Suppression of epileptiform activity by high frequency sinusoidal fields in rat hippocampal slices [J].
Bikson, M ;
Lian, J ;
Hahn, PJ ;
Stacey, WC ;
Sciortino, C ;
Durand, DM .
JOURNAL OF PHYSIOLOGY-LONDON, 2001, 531 (01) :181-191
[4]   Intrasubthalamic injection of 6-hydroxydopamine induces changes in the firing rate and pattern of subthalamic nucleus neurons in the rat [J].
Ni, ZG ;
Bouali-Benazzouz, R ;
Gao, DM ;
Benabid, AL ;
Benazzouz, A .
SYNAPSE, 2001, 40 (02) :145-153