Biological consequences of cyclobutane pyrimidine dimers

被引：102

作者：

Vink, AA ^{[1
]}

Roza, L ^{[1
]}

机构：

[1] TNO Skin Effects Testing & Photobiol, Zeist, Netherlands

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 2001年 / 65卷 / 2-3期

关键词：

DNA damage; CPD; erythema; photoimmunosuppression; photomutagenesis; photocarcinogenesis;

D O I：

10.1016/S1011-1344(01)00245-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the skin many molecules may absorb ultraviolet (UV) radiation upon exposure. In particular, cellular DNA strongly absorbs shorter wavelength solar UV radiation, resulting in various types of DNA damage. Among the DNA photoproducts produced the cyclobutane pyrimidine dithers (CPDs) are predominant. Although these lesions are efficiently repaired in the skin, this CPD formation results in various acute effects (erythema, inflammatory responses), transient effects (suppression of immune function), and chronic effects (mutation induction and skin cancer). The relationships between the presence of CPD in skin cells and the subsequent biological consequences are the subject of the present review. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：101 / 104

页数：4