Enantioselective preparation of 1-benzyloxy-3-methyl-6-heptene-2,4-diols: Total synthesis of (+)-prelactone C

被引：24

作者：

Esumi, T ^{[1
]}

Fukuyama, H ^{[1
]}

Oribe, R ^{[1
]}

Kawazoe, K ^{[1
]}

Iwabuchi, Y ^{[1
]}

Irie, H ^{[1
]}

Hatakeyama, S ^{[1
]}

机构：

[1] NAGASAKI UNIV,FAC PHARMACEUT SCI,NAGASAKI 852,JAPAN

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 27期

关键词：

D O I：

10.1016/S0040-4039(97)01042-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise method leading to all stereoisomers of 1-benzyloxy-3-methyl-6-heptene-2,4-diol from (2E,SE)-1,7-dibenzyloxy-2,5-heptadiene-4-ol has been developed. The first synthesis of (+)- prelactone C, a o-lactone isolated from the concanamycin-producing Streptomyces sp., has been achieved utilizing (2S,3S,4R)-1-benzyloxy-3-methyl-6-heptene-2,4-diol as a chiral building block. (C) 1997 Elsevier Science Ltd.

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页码：4823 / 4826

页数：4

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