Tick paralysis: development of a vaccine

被引：57

作者：

Masina, S ^{[1
]}

Broady, KW ^{[1
]}

机构：

[1] Univ Technol Sydney, Dept Cell & Mol Biol, St Leonards, NSW 2065, Australia

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 1999年 / 29卷 / 04期

关键词：

Ixodes holocyclus; neurotoxins; tick paralysis; toxicosis; vaccine;

D O I：

10.1016/S0020-7519(99)00006-5

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The paralysis tick of Australia, Ixodes holocyclus, causes a severe toxicosis in domestic animals such as dogs and cats, livestock, and in some cases, humans. II is characterised by a rapidly ascending flaccid paralysis. The causative agent of the toxicosis is a neurotoxin(s) produced in the tick salivary glands. The current treatment for tick paralysis is in the form of a polyclonal dog antiserum. This antiserum treatment is expensive and effective only in the early stages of paralysis. The aim of current research is to develop a recombinant veterinary vaccine based on the tick neurotoxin peptide sequence. A successful vaccine would provide cost-effective, long-term protective immunity against tick-induced paralysis. (C) 1999 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.

引用

页码：535 / 541

页数：7

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