Lupane Glycosides from the Leaves of Acanthopanax koreanum

被引：22

作者：

Choi, Hyun-Sik ^{[1
,2
]}

Kim, Hyoung Ja ^{[3
]}

Nam, Sang-Gil ^{[1
,2
]}

Kim, In-Seon ^{[1
,2
]}

Lee, Kyung-Tae ^{[1
,2
]}

Yook, Chang-Soo ^{[1
,2
]}

Lee, Yong Sup ^{[1
,2
]}

机构：

[1] Kyung Hee Univ, Coll Pharm, Kyung Hee EW Pharmaceut Res Inst, Dongdaemun Ku, Seoul 130701, South Korea

[2] Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Dongdaemun Ku, Seoul 130701, South Korea

[3] Korea Adv Inst Sci & Technol, Div Life Sci, Seoul 130650, South Korea

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2008年 / 56卷 / 11期

关键词：

Acanthopanax koreanum; Araliaceae; lupane glycoside; acankoreoside;

D O I：

10.1248/cpb.56.1613

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Three new lupane-type saponins, acankoreosides F-H (1-3) were isolated from the methanol extract of the leaves of Acanthopanax koreanum NAKAI. The structures of these three saponins were established by chemical and spectroscopic analysis as 3 alpha,30-dihydroxylup-20(29)-en-23,28-dioic acid 28-O-[alpha-L-rhamnopyranosyl-(1 -> 4)-beta-D-glucopyranosyl-(1 -> 6)-beta-D-glucopyransoyl] ester (2), and (20S) 3 alpha-hydroxylup-23-al-28,29-dioic acid 28-O-[alpha-L-rhamnopyranosyl-(1 -> 4)-beta-D-glucopyranosyl-(1 -> 6)-beta-D-glucopyranosyl] ester (3), respectively. The effects of the isolates (1-3) on the lipopolysaccharide-induced production of nitric oxide and prostaglandin E-2 were evaluated in RAW 264.7 macrophages.

引用

页码：1613 / 1616

页数：4

共 20 条

[1]

NATURAL-PRODUCTS FROM VIETNAMESE PLANTS .6. 3-ALPHA-HYDROXY-LUP-20(29)-ENE-23,28-DIOIC ACID FROM SCHEFFLERA-OCTOPHYLLA [J].

ADAM, G ;

LISCHEWSKI, M ;

PHIET, HV ;

PREISS, A ;

SCHMIDT, J ;

SUNG, TV .

PHYTOCHEMISTRY, 1982, 21 (06) :1385-1387

[2]

Bae, 2000, MED PLANTS KOREA, P361

[3]

Diterpenoids with inhibitory activity against NFAT transcription factor from Acanthopanax koreanum [J].

Cai, XF ;

Lee, IS ;

Dat, NT ;

Shen, GH ;

Kim, YH .

PHYTOTHERAPY RESEARCH, 2004, 18 (08) :677-680

[4]

Triterpenoids from Acanthopanax koreanum root and their inhibitory activities on NFAT transcription [J].

Cai, XF ;

Lee, IS ;

Shen, G ;

Dat, NT ;

Lee, JJ ;

Kim, YH .

ARCHIVES OF PHARMACAL RESEARCH, 2004, 27 (08) :825-828

[5]

Inhibitory Lignans against NFAT transcription factor from Acanthopanax koreanum [J].

Cai, XF ;

Lee, IS ;

Dat, NT ;

Shen, GH ;

Kang, JS ;

Kim, DH ;

Kim, YH .

ARCHIVES OF PHARMACAL RESEARCH, 2004, 27 (07) :738-741

[6]

Inhibitory effect of kaurane type diterpenoids from Acanthopanax koreanum on TNF-α secretion from trypsin-stimulated HMC-1 cells [J].

Cai, XF ;

Shen, G ;

Dat, NT ;

Kang, OH ;

Lee, YM ;

Lee, JJ ;

Kim, YH .

ARCHIVES OF PHARMACAL RESEARCH, 2003, 26 (09) :731-734

[7]

Cai XF, 2003, CHEM PHARM BULL, V51, P605, DOI 10.1248/cpb.51.605

[8]

Lupane-triterpene glycosides from leaves of Acanthopanax koreanum [J].

Chang, SY ;

Yook, CS ;

Nohara, T .

PHYTOCHEMISTRY, 1999, 50 (08) :1369-1374

[9]

Chang SY, 1998, CHEM PHARM BULL, V46, P163, DOI 10.1248/cpb.46.163

[10]

LICHENS AND FUNGI .17. THE SYNTHESIS AND ABSOLUTE-CONFIGURATION AT C-20 OF THE (R)-EPIMER AND (S)-EPIMER OF SOME 29-SUBSTITUTED LUPANE DERIVATIVES AND OF SOME 30-NORLUPAN-20-OL DERIVATIVES AND THE CRYSTAL-STRUCTURE OF (20R)-3-BETA-ACETOXYLUPAN-29-OL [J].

CORBETT, RE ;

CONG, ANT ;

WILKINS, AL ;

THOMSON, RA .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1985, (10) :2051-2056

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