Aryl radical cyclisation onto pyrroles

被引：50

作者：

Escolano, C ^{[1
]}

Jones, K ^{[1
]}

机构：

[1] Kingston Univ, Sch Chem & Pharmaceut Sci, Kingston upon Thames KT1 2EE, Surrey, England

来源：

TETRAHEDRON | 2002年 / 58卷 / 07期

关键词：

radicals; cyclisation; pyrroles; regioselection; natural products;

D O I：

10.1016/S0040-4020(02)00007-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The intramolecular cyclisation of aryl radicals onto a pyrrole is studied. The cyclisation allows the synthesis of either the spiropyrrolidinyloxindole or the pyrrolo[3,2-c]quinoline skeleton depending on the nature of the protecting group at the N-pyrrole atom. The regiochemistry of the cyclisation is not affected by the substituents on the benzene ring. Some limitations on the utility of tosylmethyl-isocyanide in pyrrole synthesis are also reported. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1453 / 1464

页数：12

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