Familial endometrial cancer in female carriers of MSH6 germline mutations

被引:304
作者
Wijnen, J
de Leeuw, W
Vasen, H
van der Klift, H
Moller, P
Stormorken, A
Meijers-Heijboer, H
Lindhout, D
Menko, F
Vossen, S
Möslein, G
Tops, C
Bröcker-Vriends, A
Wu, Y
Hofstra, R
Sijmons, R
Cornelisse, C
Morreau, H
Fodde, R [1 ]
机构
[1] Leiden Univ, Med Ctr, Dept Human & Clin Genet, MGC, NL-2300 RA Leiden, Netherlands
[2] Leiden Univ, Med Ctr, Dept Pathol, NL-2300 RA Leiden, Netherlands
[3] Leiden Univ, Med Ctr, Fdn Detect Hereditary Tumors, NL-2300 RA Leiden, Netherlands
[4] Leiden Univ, Med Ctr, Dept Gastroenterol, NL-2300 RA Leiden, Netherlands
[5] Norwegian Radium Hosp, Unit Med Genet, Oslo, Norway
[6] Erasmus Univ, Dept Clin Genet, MGC, NL-3000 DR Rotterdam, Netherlands
[7] Free Univ Amsterdam Hosp, Dept Clin Genet, Amsterdam, Netherlands
[8] Univ Dusseldorf, Dept Surg, D-4000 Dusseldorf, Germany
[9] Leiden Univ, Med Ctr, Clin Genet Ctr Leiden, NL-2300 RA Leiden, Netherlands
[10] Univ Groningen, Dept Med Genet, Groningen, Netherlands
关键词
D O I
10.1038/13773
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
引用
收藏
页码:142 / 144
页数:3
相关论文
共 15 条
[1]  
Akiyama Y, 1997, CANCER RES, V57, P3920
[2]  
Boland CR, 1998, CANCER RES, V58, P5248
[3]   ISOLATION OF AN HMSH2-P160 HETERODIMER THAT RESTORES DNA MISMATCH REPAIR TO TUMOR-CELLS [J].
DRUMMOND, JT ;
LI, GM ;
LONGLEY, MJ ;
MODRICH, P .
SCIENCE, 1995, 268 (5219) :1909-1912
[4]   Isolation of MutSβ from human cells and comparison of the mismatch repair specificities of MutSβ and MutSα [J].
Genschel, J ;
Littman, SJ ;
Drummond, JT ;
Modrich, P .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (31) :19895-19901
[5]   UBIQUITOUS SOMATIC MUTATIONS IN SIMPLE REPEATED SEQUENCES REVEAL A NEW MECHANISM FOR COLONIC CARCINOGENESIS [J].
IONOV, Y ;
PEINADO, MA ;
MALKHOSYAN, S ;
SHIBATA, D ;
PERUCHO, M .
NATURE, 1993, 363 (6429) :558-561
[6]   MUTATIONS OF THE TRANSFORMING GROWTH-FACTOR-BETA TYPE-II RECEPTOR GENE AND GENOMIC INSTABILITY IN HEREDITARY NONPOLYPOSIS COLORECTAL-CANCER [J].
LU, SL ;
AKIYAMA, Y ;
NAGASAKI, H ;
SAITOH, K ;
YUASA, Y .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 216 (02) :452-457
[7]   GENETICS, NATURAL-HISTORY, TUMOR SPECTRUM, AND PATHOLOGY OF HEREDITARY NONPOLYPOSIS COLORECTAL-CANCER - AN UPDATED REVIEW [J].
LYNCH, HT ;
SMYRK, TC ;
WATSON, P ;
LANSPA, SJ ;
LYNCH, JF ;
LYNCH, PM ;
CAVALIERI, RJ ;
BOLAND, CR .
GASTROENTEROLOGY, 1993, 104 (05) :1535-1549
[8]   Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer [J].
Miyaki, M ;
Konishi, M ;
Tanaka, K ;
KikuchiYanoshita, R ;
Muraoka, M ;
Yasuno, M ;
Igari, T ;
Koike, M ;
Chiba, M ;
Mori, T .
NATURE GENETICS, 1997, 17 (03) :271-272
[9]   Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study [J].
Peltomaki, P ;
Vasen, HFA ;
Bisgaard, ML ;
Buerstedde, JM ;
Friedl, W ;
Grandjouan, S ;
Hutter, P ;
KohonenCorish, M ;
Kolodner, R ;
Kurzawski, G ;
Lindblom, A ;
Lynch, HT ;
Piepoli, A ;
deLeon, MP ;
Radice, P ;
Thibodeau, S ;
Weber, W ;
West, S ;
Wijnen, J .
GASTROENTEROLOGY, 1997, 113 (04) :1146-1158
[10]   New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch Syndrome) proposed by the International Collaborative Group n HNPCC [J].
Vasen, HFA ;
Watson, P ;
Mecklin, JP ;
Lynch, HT .
GASTROENTEROLOGY, 1999, 116 (06) :1453-1456