A new type of orally active insulin-mimetic vanadyl complex:: Bis(1-oxy-2-pyridinethiolato)oxovanadium(IV) with VO(S2O2) coordination mode

被引：43

作者：

Sakurai, H ^{[1
]}

Sano, H ^{[1
]}

Takino, T ^{[1
]}

Yasui, H ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Dept Analyt & Bioinorgan Chem, Yamashima Ku, Kyoto 6078414, Japan

来源：

CHEMISTRY LETTERS | 1999年 / 09期

关键词：

D O I：

10.1246/cl.1999.913

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new purple vanadyl complex, bis(1-oxy-2-pyridinethiolato) oxovanadium(IV), VO(OPT), with VO(S2O2) coordination mode, was prepared by mixing 2-mercaptopyridine-N-oxide or 1-hydroxy-2-pyridinethione and VOSO4,, and characterized by UV, IR and EPR spectra, magnetic susceptibility and partition coefficient. Based on the higher in vitro insulin-mimetic activity of VO(OPT) (IC50=0.19 mM) than that of VOSO4, (IC50=0.9 mM), the complex was found to be a potent agent for treating insulin-dependent diabetes mellitus in rats when given by daily intravenous injection or oral administration.

引用

页码：913 / 914

页数：2

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