Efficient transfer of information from hexitol nucleic acids to RNA during nonenzymatic oligomerization

被引：45

作者：

Kozlov, IA

De Bouvere, B

Van Aerschot, A

Herdewijn, P

Orgel, LE

机构：

[1] Salk Inst Biol Studies, San Diego, CA 92186 USA

[2] Katholieke Univ Leuven, Rega Inst, Med Chem Lab, B-3000 Louvain, Belgium

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1999年 / 121卷 / 25期

关键词：

D O I：

10.1021/ja990440u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hexitol nucleic acids (HNAs) are DNA analogues that contain the standard nucleoside bases attached to a phosphorylated 1,5-anhydrohexitol backbone. We find that HNAs support efficient information transfer in nonenzymatic template-directed reactions. HNA heterosequences appeared to be superior to the corresponding DNA heterosequences in facilitating synthesis of complementary oligonucleotides from nucleoside-5'-phosphoro-2-methyl imidazolides.

引用

页码：5856 / 5859

页数：4