Chemical and Pharmacological Aspects of the Genus Calophyllum

被引：48

作者：

Cechinel Filho, Valdir ^{[1
]}

Meyre-Silva, Christiane

Niero, Rivaldo

机构：

[1] Univ Vale Itajai, Programa Mestrado Ciencias Farmaceut, CCS, BR-88302202 Itajai, SC, Brazil

来源：

CHEMISTRY & BIODIVERSITY | 2009年 / 6卷 / 03期

关键词：

NATURAL-PRODUCTS; ANTIMICROBIAL ACTIVITY; STRUCTURE ELUCIDATION; ANTIFUNGAL XANTHONES; MEDICINAL-PLANTS; ROOT BARK; BRASILIENSE; COUMARINS; INHIBITION; PYRANOCOUMARINS;

D O I：

10.1002/cbdv.200800082

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The Calophyllum genus (Clusiaceac) is composed of ca. 200 species, with a pantropical distribution. Some species are used as medicinal agents to treat a large number of diseases, including gastric Ulcers, infections, pain, tumors, and inflammatory processes, among others. A review of the literature regarding the chemical and biological aspects of these plants indicates cytotoxic activity against several cell lines, inhibition of HIV-1 reverse transcriptase, antisecretory and cytoprotective properties, antinociceptive, molluscicidal and antimicrobial effects, etc., related particularly to the presence of coumarins. xanthones. flavonoids, and triterpenes. This review, therefore. deals with the chemistry, and pharmacology or biology of the main plants belonging to the genus Calophyllum, with particular emphasis on C. brusiliense. studied by our research group.

引用

页码：313 / 327

页数：15

共 74 条

[1]

Epimers from the leaves of Calophyllum inophyllum [J].