New chromanone acids with antibacterial activity from Calophyllum brasiliense

被引：77

作者：

Cottiglia, F

Dhanapal, B

Sticher, O

Heilmann, J ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, Inst Pharmaceut Sci, Dept Chem & Appl Biosci, CH-8057 Zurich, Switzerland

[2] Univ Cagliari, Fac Farm, Dipartimento Farmaco Chim Tecnol, I-09124 Cagliari, Italy

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 04期

关键词：

D O I：

10.1021/np030438n

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six novel chromanone acids (1-6) were isolated from the bark of Calophyllum brasiliense Cambess. Their structures were elucidated on the basis of 1D and 2D NMR experiments, as well as mass spectrometry. All compounds showed moderate to strong antibacterial activity against Bacillus cereus and Staphylococcus epidermidis, with 1 and 2 being most active. None of the compounds were cytotoxie against KB, Jurkat T, and myosarcoma cancer cells up to 20 mug/mL.

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页码：537 / 541

页数：5

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