Cell adhesion molecules and adhesion abnormalities in prostate cancer

被引：35

作者：

Mason, MD

Davies, G

Jiang, WG

机构：

[1] Cardiff Univ, Dept Clin Oncol, Cardiff CF14 4XN, S Glam, Wales

[2] Cardiff Univ, Dept Surg, Cardiff CF14 4XN, S Glam, Wales

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2002年 / 41卷 / 01期

关键词：

beta-catenin; cadherin; prostate cancer; cell adhesion;

D O I：

10.1016/S1040-8428(01)00171-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Prostate cancer, the leading male cancer in Western countries, has accelerated in its incidence in the past decade. Patients with prostate cancer frequently have a poor prognosis as a result of local or distant spread of cancer. This review summaries some of the recent progress made in understanding the biology of cancer metastasis with a special emphasis on the role of cell adhesion molecules and adhesion abnormalities. The molecular and cellular function of cell adhesion molecules, their role in cancer and cancer progression, the clinical impact of these molecules, and therapeutic considerations are also discussed. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：11 / 28

页数：18

共 167 条

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