Responses of microglia and neural progenitors to mechanical brain injury

被引：49

作者：

Tzeng, SF ^{[1
]}

Wu, JP ^{[1
]}

机构：

[1] Taichung Vet Gen Hosp, Dept Res & Educ, Taichung 40705, Taiwan

来源：

NEUROREPORT | 1999年 / 10卷 / 11期

关键词：

apoptosis; brain injury; microglia; NF kappa B; neural progenitors; subventricular zone/ventricular zone;

D O I：

10.1097/00001756-199908020-00012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

NEURAL cells have distinct responses to CNS injury; however, neural progenitor response to CNS injury is not yet documented. Stab injury combined with injection of bromodeoxyuridine (BrdU), a thymidine analog, into adult rat cortex above the lateral ventricle for 10 min resulted in activated microglia/macrophage infiltration along with nuclear factor kappa B (NF kappa B)/ p65 activation at the lesion site. Most NF kappa B/p65+ cells displayed a phagocytic morphology. Under these conditions, profound cell apoptosis took place in the injured corpus callosum, but not in the subventricular/ ventricular zone (SVZ/VZ). The SVZ/VZ-derived neural progenitors in both injected and non-injected contralateral hemispheres showed strong BrdU immunostaining, indicating that SVZ/VZ-derived neural progenitors of both hemispheres may undergo DNA synthesis in response to unilateral brain injury. NeuroReport 10:2287-2292 (C) 1999 Lippincott Williams & Wilkins.

引用

页码：2287 / 2292

页数：6

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