The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activation

被引：176

作者：

Gerondakis, S ^{[1
]}

Grumont, R ^{[1
]}

Rourke, I ^{[1
]}

Grossmann, M ^{[1
]}

机构：

[1] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

来源：

CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0952-7915(98)80175-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The activation of B and T cells by a wide range of stimuli can rapidly induce specific gene expression via a mechanism that promotes the nuclear translocation of different Rel/nuclear factor-kappa B (NF-kappa B) transcription factors which are normally resident in the cytoplasm. Recent findings highlight the crucial roles of specific Rel/NF-kappa B family members in the processes of cell division, apoptosis and differentiation that accompany lymphocyte activation.

引用

页码：353 / 359

页数：7

共 48 条

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