The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activation

被引：176

作者：

Gerondakis, S ^{[1
]}

Grumont, R ^{[1
]}

Rourke, I ^{[1
]}

Grossmann, M ^{[1
]}

机构：

[1] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

来源：

CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0952-7915(98)80175-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The activation of B and T cells by a wide range of stimuli can rapidly induce specific gene expression via a mechanism that promotes the nuclear translocation of different Rel/nuclear factor-kappa B (NF-kappa B) transcription factors which are normally resident in the cytoplasm. Recent findings highlight the crucial roles of specific Rel/NF-kappa B family members in the processes of cell division, apoptosis and differentiation that accompany lymphocyte activation.

引用

页码：353 / 359

页数：7

共 48 条

[21] Different nuclear signals are activated by the B cell receptor during positive versus negative signaling
Healy, JI
Dolmetsch, RE
Timmerman, LA
Cyster, JG
Thomas, ML
Crabtree, GR
Lewis, RS
Goodnow, CC
[J]. IMMUNITY, 1997, 6 (04) : 419 - 428
[22] High mobility group protein I(Y) is required for function and for c-Rel binding to CD28 response elements within the GM-CSF and IL-2 promoters
Himes, SR
Coles, LS
Reeves, R
Shannon, MF
[J]. IMMUNITY, 1996, 5 (05) : 479 - 489
[23] Failure of lymphopoiesis after adoptive transfer of NF-kappa B-deficient fetal liver cells
Horwitz, BH
Scott, ML
Cherry, SR
Bronson, RT
Baltimore, D
[J]. IMMUNITY, 1997, 6 (06) : 765 - 772
[24] Iciek LA, 1997, J IMMUNOL, V158, P4769
[25] TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling
Ishida, T
Tojo, T
Aoki, T
Kobayashi, N
Ohishi, T
Watanabe, T
Yamamoto, T
Inoue, J
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (18) : 9437 - 9442
[26] Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-kappa B2
Ishikawa, H
Carrasco, D
Claudio, E
Ryseck, RP
Bravo, R
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (07) : 999 - 1014
[27] MICE LACKING THE C-REL PROTOONCOGENE EXHIBIT DEFECTS IN LYMPHOCYTE-PROLIFERATION, HUMORAL IMMUNITY, AND INTERLEUKIN-2 EXPRESSION
KONTGEN, F
GRUMONT, RJ
STRASSER, A
METCALF, D
LI, RL
TARLINTON, D
GERONDAKIS, S
[J]. GENES & DEVELOPMENT, 1995, 9 (16) : 1965 - 1977
[28] TRAF2 is essential for JNK but not NF-kappa B activation and regulates lymphocyte proliferation and survival
Lee, SY
Reichlin, A
Santana, A
Sokol, KA
Nussenzweig, MC
Choi, Y
[J]. IMMUNITY, 1997, 7 (05) : 703 - 713
[29] Regulation of the interleukin-2 CD28-responsive element by NF-ATp and various NF-kappa B/Rel transcription factors
Maggirwar, SB
Harhaj, EW
Sun, SC
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (05) : 2605 - 2614
[30] IKK-1 and IKK-2: Cytokine-activated I kappa B kinases essential for NF-kappa B activation
Mercurio, F
Zhu, HY
Murray, BW
Shevchenko, A
Bennett, BL
Li, JW
Young, DB
Barbosa, M
Mann, M
[J]. SCIENCE, 1997, 278 (5339) : 860 - 866

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