State of the art: Using natriuretic peptide levels in clinical practice

被引：652

作者：

Maisel, Alan ^{[1
]}

Mueller, Christian ^{[2
]}

Adams, Kirkwood, Jr. ^{[3
]}

Anker, Stefan D. ^{[4
]}

Aspromonte, Nadia ^{[5
]}

Cleland, John G. F. ^{[6
]}

Cohen-Solal, Alain ^{[7
]}

Dahlstrom, Ulf ^{[8
]}

DeMaria, Anthony ^{[9
]}

Di Somma, Salvatore ^{[10
]}

Filippatos, Gerasimos S. ^{[11
]}

Fonarow, Gregg C. ^{[12
]}

Jourdain, Patrick ^{[13
]}

Komajda, Michel ^{[14
]}

Liu, Peter P. ^{[15
]}

McDonagh, Theresa ^{[16
]}

McDonald, Kenneth ^{[17
]}

Mebazaa, Alexandre ^{[18
]}

Nieminen, Markku S. ^{[19
]}

Peacock, W. Frank ^{[20
]}

Tubaro, Marco ^{[21
]}

Valle, Roberto ^{[22
]}

Vanderhyden, Marc ^{[23
]}

Yancy, Clyde W. ^{[24
]}

Zannad, Faiez ^{[25
]}

Braunwald, Eugene ^{[26
]}

机构：

[1] VA San Diego Healthcare Syst, San Diego, CA USA

[2] Univ Basel Hosp, Basel, Switzerland

[3] Univ N Carolina, Chapel Hill, NC USA

[4] Campus Virchow Klinikum, Charite, Berlin, Germany

[5] San Spirito Hosp, Rome, Italy

[6] Univ Hull, Castle Hill Hosp, Kingston Upon Hull, Yorks, England

[7] Hop Lariboisiere, F-75475 Paris, France

[8] Linkoping Univ Hosp, S-58185 Linkoping, Sweden

[9] Univ Calif San Diego, San Diego, CA 92103 USA

[10] Univ Roma La Sapienza, St Andreas Hosp, Rome, Italy

[11] Univ Athens, Hosp Attikon, Athens, Greece

[12] Univ Calif Los Angeles, Los Angeles, CA USA

[13] Paris Descartes Univ, Paris, France

[14] Univ Paris 06, Pitie Salpetriere Hosp, Dept Cardiol, Paris, France

[15] Univ Toronto, Toronto, ON, Canada

[16] Royal Brompton Hosp, London SW3 6LY, England

[17] St Vincents Univ Hosp, Dublin 4, Ireland

[18] Univ Paris 07, Hop Lariboisiere, Paris, France

[19] Univ Helsinki, Cent Hosp, Helsinki, Finland

[20] Cleveland Clin, Cleveland, OH 44106 USA

[21] San Filippo Neri Hosp, Rome, Italy

[22] Osped Civile, Ctr Scompenso, San Dona Di Piave, Italy

[23] Onze Lieve Vrouwe Ziekenhuis, Aalst, Belgium

[24] Baylor Univ, Med Ctr, Dallas, TX USA

[25] Ctr Invest Clin, INSERM, Nancy, France

[26] Brigham & Womens Hosp, Boston, MA 02115 USA

来源：

EUROPEAN JOURNAL OF HEART FAILURE | 2008年 / 10卷 / 09期

关键词：

Natriuretic peptides; Clinical practice; Diagnosis;

D O I：

10.1016/j.ejheart.2008.07.014

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Natriuretic peptide (NP) levels (B-type natriuretic peptide (BNP) and N-terminal proBNP) are now widely used in clinical practice and cardiovascular research throughout the world and have been incorporated into most national and international cardiovascular guidelines for heart failure. The role of NP levels in state-of-the-art clinical practice is evolving rapidly. This paper reviews and highlights ten key messages to clinicians: NP levels are quantitative plasma biomarkers of heart failure (HF). NP levels are accurate in the diagnosis of FIR NP levels may help risk stratify emergency department (ED) patients with regard to the need for hospital admission or direct ED discharge. NP levels help improve patient management and reduce total treatment costs in patients with acute dyspnoea. NP levels at the time of admission are powerful predictors of outcome in predicting death and re-hospitalisation in HF patients. NP levels at discharge aid in risk stratification of the HF patient. NP-guided therapy may improve morbidity and/or mortality in chronic HF. The combination of NP levels together with symptoms, signs and weight gain assists in the assessment of clinical decompensation in HE NP levels can accelerate accurate diagnosis of heart failure presenting in primary care. NP levels may be helpful to screen for asymptomatic left ventricular dysfunction in high-risk patients. Published by Elsevier B.V. on behalf of European Society of Cardiology.

引用

页码：824 / 839

页数：16

共 105 条

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