Chromosomal organisation of a gene family encoding rhoptry proteins in Plasmodium yoelii

被引：26

作者：

Owen, CA ^{[1
]}

Sinha, KA ^{[1
]}

Keen, JK ^{[1
]}

Ogun, SA ^{[1
]}

Holder, AA ^{[1
]}

机构：

[1] Natl Inst Med Res, Div Parasitol, London NW7 1AA, England

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1999年 / 99卷 / 02期

基金：

英国医学研究理事会;

关键词：

malaria; Plasmodium yoelii; rhoptry protein; multigene family; chromosome;

D O I：

10.1016/S0166-6851(99)00015-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The genomic organisation of the genes coding for a group of high molecular mass rhoptry proteins of the rodent malaria parasite Plasmodium yoelii YM was investigated using blotting, two dimensional gel electrophoresis and restriction fragment length analysis. The genes were found on chromosomes 1, 5, 6 and 10, with the possibility that related genes were also present on chromosomes 3 and 4. On chromosome 1 the genes were located close to one end, whereas they were present at both ends of chromosome 5, 6 and 10. Two genes, e3 and e8, that had been partially characterised previously were present on chromosomes 5 and 1, respectively. Based on an analysis of the 3' end of the genes, three subfamilies present on chromosomes 1, 5 and 6, and 10, respectively, were identified. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：183 / 192

页数：10

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