The ubiquitin-selective chaperone CDC-48/p97, a new player in DNA replication

被引：19

作者：

Deichsel, Alexandra ^{[2
]}

Mouysset, Julien ^{[2
]}

Hoppe, Thorsten ^{[1
,2
]}

机构：

[1] Univ Cologne, Inst Genet, Cologne Excellence Cluster Cellular Stress Respon, D-50674 Cologne, Germany

[2] Univ Hamburg, Ctr Mol Neurobiol ZMNH, Hamburg, Germany

来源：

CELL CYCLE | 2009年 / 8卷 / 02期

关键词：

DNA replication initiation; AAA(+) ATPases; CDC-48/p97; pre-replicative complex; origin recognition; VALOSIN-CONTAINING PROTEIN; CELL-DIVISION-CYCLE; AAA PLUS ATPASES; ORIGIN RECOGNITION; RNA-BINDING; COMPLEX; CHROMATIN; TRANSCRIPTION; DEGRADATION; PROTEASOME;

D O I：

10.4161/cc.8.2.7356

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Efficient duplication of the genome and its equal distribution into both daughter cells is an essential process for all dividing organisms. To ensure that DNA replication occurs only once during the S phase of the cell cycle, initiation of replication is tightly controlled. Initiation factors are responsible for the recruitment of the replisome, the large molecular machine carrying out DNA synthesis, to origins of replication and license them to start DNA duplication. Remarkably, most of the currently known initiators have been classified as members of the family of AAA(+) ATPases. 1 In our recent study we identified an additional AAA+ ATPase, CDC-48, to be essential for proper DNA replication in Caenorhabditis elegans. 2 Here, we speculate on the function of CDC-48 (also known as Cdc48p in yeast and p97 in vertebrates) during DNA replication initiation, addressing its ubiquitin-selective chaperone activity.

引用

页码：185 / 190

页数：6

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