Regulation of p53 by Mdm2: Fate is in the numbers

被引：47

作者：

Shmueli, A ^{[1
]}

Oren, M ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel

来源：

MOLECULAR CELL | 2004年 / 13卷 / 01期

关键词：

D O I：

10.1016/S1097-2765(03)00529-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The p53 tumor suppressor protein is normally restrained by the Mdm2 oncoprotein, which promotes p53 ubiquitination. In a recent issue of Science, Li et al. (2003) report that p53 may face two alternative fates, depending on Mdm2 levels: high Mdm2 drives p53 polyubiquitination and degradation within the cell nucleus, whereas low Mdm2 promotes p53 monoubiquitination and nuclear exclusion.

引用

页码：4 / 5

页数：2

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