Intercellular adhesion, signalling and the cytoskeleton

被引:473
作者
Jamora, C [1 ]
Fuchs, E [1 ]
机构
[1] Univ Chicago, Howard Hughes Med Inst, Dept Mol Genet & Cell Biol, Chicago, IL 60637 USA
关键词
D O I
10.1038/ncb0402-e101
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Connections between the cytoskeleton and intercellular junctions profoundly influence cell shape and motility. It is becoming increasingly clear that in addition to structural functions, components of the adhesion apparatus also possess signalling capabilities. Recent studies suggest that their dual function may provide the means to integrate changes in morphology and gene expression during tissue and organ development.
引用
收藏
页码:E101 / E108
页数:8
相关论文
共 109 条
  • [11] Wnt signaling: a common theme in animal development
    Cadigan, KM
    Nusse, R
    [J]. GENES & DEVELOPMENT, 1997, 11 (24) : 3286 - 3305
  • [12] Plakoglobin suppresses epithelial proliferation and hair growth in vivo.
    Charpentier, E
    Lavker, RM
    Acquista, E
    Cowin, P
    [J]. JOURNAL OF CELL BIOLOGY, 2000, 149 (02) : 503 - 519
  • [13] Cadherin-mediated regulation of microtubule dynamics
    Chausovsky, A
    Bershadsky, AD
    Borisy, GG
    [J]. NATURE CELL BIOLOGY, 2000, 2 (11) : 797 - 804
  • [14] CHEN YT, 1994, J CELL BIOL, V4, P687
  • [15] Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation
    Chidgey, M
    Brakebusch, C
    Gustafsson, E
    Cruchley, A
    Hail, C
    Kirk, S
    Merritt, A
    North, A
    Tselepis, C
    Hewitt, J
    Byrne, C
    Fassler, R
    Garrod, D
    [J]. JOURNAL OF CELL BIOLOGY, 2001, 155 (05) : 821 - 832
  • [16] FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak
    Ciruna, B
    Rossant, J
    [J]. DEVELOPMENTAL CELL, 2001, 1 (01) : 37 - 49
  • [17] The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
    Comijn, J
    Berx, G
    Vermassen, P
    Verschueren, K
    van Grunsven, L
    Bruyneel, E
    Mareel, M
    Huylebroeck, D
    van Roy, F
    [J]. MOLECULAR CELL, 2001, 7 (06) : 1267 - 1278
  • [18] DasGupta R, 1999, DEVELOPMENT, V126, P4557
  • [19] Binding to cadherins antagonizes the signaling activity of beta-catenin during axis formation in Xenopus
    Fagotto, F
    Funayama, N
    Gluck, U
    Gumbiner, BM
    [J]. JOURNAL OF CELL BIOLOGY, 1996, 132 (06) : 1105 - 1114
  • [20] At the roots of a never-ending cycle
    Fuchs, E
    Merrill, BJ
    Jamora, C
    DasGupta, R
    [J]. DEVELOPMENTAL CELL, 2001, 1 (01) : 13 - 25