Synthesis of ganglioside epitopes for oligosaccharide specific immunoadsorption therapy of Guillian-Barre syndrome

被引:32
作者
Andersen, SM [1 ]
Ling, CC
Zhang, P
Townson, K
Willison, HJ
Bundle, DR
机构
[1] Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada
[2] Univ Glasgow, So Gen Hosp, Dept Neurol, Div Clin Neurosci, Glasgow G51 4TF, Lanark, Scotland
[3] Univ Glasgow, Dept Chem, Glasgow G4 0BA, Lanark, Scotland
关键词
D O I
10.1039/b400029c
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Guillain-Barre syndrome is a postinfectious, autoimmune neuropathy resulting in neuromuscular paralysis. Auto-antibodies, often induced by bacterial infection, bind to human gangliosides possessing monosialoside and diasialoside epitopes and impair the function of nerve junctions, where these ganglioside structures are highly enriched. Truncated gangliosides representive of GD(3), GQ(1b) and GM(2) epitopes have been synthesized as methyl glycosides and as a glycosides of an eleven carbon tether. The synthetic oligosaccharide ligands are structural mimics of these highly complex ganglioside epitopes and via their ability to neutralize or remove auto-antibodies have the potential for therapy, either as soluble blocking ligands administered systemically, or as immuno-affinity ligands for use as extracorporeal immunoadsorbents.
引用
收藏
页码:1199 / 1212
页数:14
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