A novel method to highly versatile monomeric PNA building blocks by multi component reactions

被引：29

作者：

Dömling, A

Chi, KZ

Barrère, M

机构：

[1] Morphochem AG, D-82152 Martinsried, Germany

[2] Tech Univ Munich, Inst Organ Chem & Biochem, D-85747 Garching, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 19期

关键词：

PNA; MCR; combinatorial chemistry; Ugi reaction;

D O I：

10.1016/S0960-894X(99)00491-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel approach to monomeric PNA building blocks by a solution phase Ugi multi component reaction (MCR) is described. The reaction is easily performed in 96 well plates. The products precipitate from the reaction solution and are thus obtained in high yields and purity. Those products are not amenable by another multi step synthesis in such a diversity. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：2871 / 2874

页数：4

共 12 条

[1] MCR .3. Multicomponent reactions and their libraries, a new type of organic chemistry of the isocyanides and phosphorus derivatives.
Chattopadhyaya, J
Domling, A
Lorenz, K
Richter, W
Ugi, I
Werner, B
[J]. NUCLEOSIDES & NUCLEOTIDES, 1997, 16 (5-6): : 843 - 848
[2] ANTISENSE OLIGONUCLEOTIDES
DEMESMAEKER, A
HANER, R
MARTIN, P
MOSER, HE
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1995, 28 (09) : 366 - 374
[3] Dömling A, 1998, COMB CHEM HIGH T SCR, V1, P1
[4] THE BETA-LACTAM-NUCLEOSIDE CHIMERA
DOMLING, A
STARNECKER, M
UGI, I
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1995, 34 (20): : 2238 - 2239
[5] A novel concept for the combinatorial synthesis of peptide nucleic acids.
Dömling, A
[J]. NUCLEOSIDES & NUCLEOTIDES, 1998, 17 (9-11): : 1667 - 1670
[6] Combinatorial generation of nucleobase libraries by MCR
Domling, A
Richter, W
Ugi, I
[J]. NUCLEOSIDES & NUCLEOTIDES, 1997, 16 (7-9): : 1753 - 1756
[7] DOMLING A, 1996, Patent No. 102860
[8] DOMLING A, 1999, UNPUB ANGEW CHEM INT, P38
[9] HYRUP B, 1996, BIOMED CHEM LETT, V6, P5
[10] Modified PNAs: A simple method for the synthesis of monomeric building blocks
Maison, W
Schlemminger, I
Westerhoff, O
Martens, J
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (04) : 581 - 584

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