The role of the left Brodmann's areas 44 and 45 in reading words and pseudowords

被引：106

作者：

Heim, S ^{[1
]}

Alter, K

Ischebeck, AK

Amunts, K

Eickhoff, SB

Mohlberg, H

Zilles, K

von Cramon, DY

Friederici, AD

机构：

[1] AG Brain Mapping, Res Ctr Julich, Inst Med, D-52425 Julich, Germany

[2] BICW, Julich, Germany

[3] Max Planck Inst Human Cognit & Brain Sci, Leipzig, Germany

[4] Univ Newcastle, Sch Med, Sch Neurol Neurobiol & Psychiat, Newcastle Upon Tyne, Tyne & Wear, England

[5] Univ Innsbruck, Sch Med, Neurol Clin, Innsbruck, Austria

[6] Rhein Westfal TH Aachen, Dept Psychiat & Psychotherapy, Aachen, Germany

[7] Univ Dusseldorf, C&O Vogt Inst Hirnforsch, Dusseldorf, Germany

来源：

COGNITIVE BRAIN RESEARCH | 2005年 / 25卷 / 03期

关键词：

Broca's area; BA; 44; 45; grapheme-to-phoneme conversion; lexical search; visual word recognition;

D O I：

10.1016/j.cogbrainres.2005.09.022

中图分类号：

TP18 [人工智能理论];

学科分类号：

081104 ; 0812 ; 0835 ; 1405 ;

摘要：

In this functional magnetic resonance imaging (fMRI) study, we investigated the influence of two task (lexical decision, LDT; phonological decision, PDT) on activation in Broca's region (left Brodmann's areas [BA] 44 and 45) during the processing of visually presented words and pseudowords. Reaction times were longer for pseudowords than words in LDT but did not differ in PDT. By combining the fMRI data with cytoarchitectonic anatomical probability maps, we demonstrated that the left BA 44 and BA 45 were stronger activated for pseudowords than for words. Separate analyses for LDT and PDT revealed that the left BA 44 was activated in both tasks, whereas left BA 45 was only involved in LDT. The results are interpreted within a dual-route model of reading with the left BA 44 supporting grapheme-to-phoneme conversion and the left BA 45 being related to explicit lexical search. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：982 / 993

页数：12

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