Gain, Preservation, and Loss of a Group 1a Coronavirus Accessory Glycoprotein

被引：76

作者：

Lorusso, Alessio ^{[1
,2
]}

Decaro, Nicola ^{[2
]}

Schellen, Pepijn ^{[1
]}

Rottier, Peter J. M. ^{[1
]}

Buonavoglia, Canio ^{[2
]}

Haijema, Bert-Jan ^{[1
]}

de Groot, Raoul J. ^{[1
]}

机构：

[1] Univ Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, Div Virol, NL-3584 CL Utrecht, Netherlands

[2] Fac Vet Med, Dept Publ Hlth & Zootechn, Bari, Italy

来源：

JOURNAL OF VIROLOGY | 2008年 / 82卷 / 20期

关键词：

D O I：

10.1128/JVI.01031-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Coronaviruses are positive-strand RNA viruses of extraordinary genetic complexity and diversity. In addition to a common set of genes for replicase and structural proteins, each coronavirus may carry multiple group-specific genes apparently acquired through relatively recent heterologous recombination events. Here we describe an accessory gene, ORF3, unique to canine coronavirus type I (CCoV-I) and characterize its product, glycoprotein gp3. Whereas ORF3 is conserved in CCoV-I, only remnants remain in CCoV-II and CCoV-II-derived porcine and feline coronaviruses. Our findings provide insight into the evolutionary history of coronavirus group 1a and into the dynamics of gain and loss of accessory genes.

引用

页码：10312 / 10317

页数：6

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