In vivo antitumor effects of electrochemotherapy in a hepatoma model

被引：67

作者：

Jaroszeski, MJ ^{[1
]}

Gilbert, RA ^{[1
]}

Heller, R ^{[1
]}

机构：

[1] UNIV S FLORIDA, DEPT CHEM ENGN, TAMPA, FL 33612 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 1997年 / 1334卷 / 01期

关键词：

electrochemotherapy; bleomycin; hepatoma; electroporation; chemotherapy; (rat liver);

D O I：

10.1016/S0304-4165(96)00147-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The use of in vivo electroporation in combination with a chemotherapeutic agent (electrochemotherapy) for the treatment of liver tumors was examined. Induced rat hepatomas were treated with a 0.5 unit intratumor bleomycin dose followed by rectangular direct current pulses. Six pulses were administered during treatment using a needle array electrode that rotated the applied electric field around the tumors. A 84.6% objective response rate resulted for tumors that received both bleomycin and electric pulses. Control groups that received partial or no treatment showed less than 10% objective response rates. These results indicate that electrochemotherapy can be translated from the treatment of cutaneous cancers to the treatment of liver tumors and other internal tumors.

引用

页码：15 / 18

页数：4

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