Early changes in nitric oxide synthase activity in atrial intramural arteries following experimental spinal cord injury in rats

被引：5

作者：

Bravo, G

Larios, F

Rojas-Martínez, R

Hong, E

Salazar, LA

Guízar-Sahagún, G

机构：

[1] IPN, CINVESTAV, Dept Farmacol & Toxicol, Sect Terapeut Expt, Mexico City 16020, DF, Mexico

[2] IMSS Proyecto Camina AC, Mexico City, DF, Mexico

来源：

NEUROSCIENCE LETTERS | 1999年 / 271卷 / 01期

关键词：

spinal cord injury; cardiovascular effects; NADPH-d technique; nitric oxide;

D O I：

10.1016/S0304-3940(99)00495-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previously, we have shown that immediately after an experimental spinal cord injury (SCI) in anaesthetized rats, there is a large fall in mean arterial pressure (MAP) and heart rate (HR), followed by an abrupt increase in MAP. To evaluate the participation of nitric oxide (NO), we evaluated the activity of nitric oxide synthase (NOS) using Nicotinamide adenine dinucleotide phosphate (NADPH) diaphorase histochemistry in sections of atria at several post-injury time-intervals. Staining increased at 3 min, reached a maximum at 9 min and diminished 30 min after injury. Pretreatment with atropine prevented changes in MAP, HR and NADPH-d staining suggesting that such modifications result from an increased vagal stimulation. In conclusion, the NOS activity is transiently elevated in the atrial intramural arteries of rats subjected to an SCI. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：37 / 40

页数：4

共 18 条

[1]

Allen A., 1911, J AM MED ASS, V57, P878, DOI 10.1001/jama.1911.04260090100008

[2] NITRIC-OXIDE SYNTHASE PROTEIN AND MESSENGER-RNA ARE DISCRETELY LOCALIZED IN NEURONAL POPULATIONS OF THE MAMMALIAN CNS TOGETHER WITH NADPH DIAPHORASE [J].