Fas Death Receptor Enhances Endocytic Membrane Traffic Converging into the Golgi Region

被引:24
作者
Degli Esposti, Mauro [1 ]
Tour, Julien [1 ]
Ouasti, Sihem [1 ]
Ivanova, Saska [2 ]
Matarrese, Paola [3 ]
Malorni, Walter [3 ]
Khosravi-Far, Roya [4 ]
机构
[1] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England
[2] Jozef Stefan Inst, Dept Biochem Struct & Mol Biol, Ljubljana 1000, Slovenia
[3] Ist Super Sanita, Dept Drug Res & Evaluat, Sect Cell Aging & Degenerat, I-00161 Rome, Italy
[4] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02215 USA
基金
英国生物技术与生命科学研究理事会; 美国国家卫生研究院;
关键词
CLATHRIN-INDEPENDENT ENDOCYTOSIS; GPI-ANCHORED PROTEINS; JURKAT T-LYMPHOCYTES; CELL-SURFACE; II CELLS; RECYCLING ENDOSOMES; PLASMA-MEMBRANE; KEY ROLE; APOPTOSIS; ACTIVATION;
D O I
10.1091/mbc.E08-09-0925
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The death receptor Fas/CD95 initiates apoptosis by engaging diverse cellular organelles including endosomes. The link between Fas signaling and membrane traffic has remained unclear, in part because it may differ in diverse cell types. After a systematic investigation of all known pathways of endocytosis, we have clarified that Fas activation opens clathrin-independent portals in mature T cells. These portals drive rapid internalization of surface proteins such as CD59 and depend upon actin-regulating Rho GTPases, especially CDC42. Fas-enhanced membrane traffic invariably produces an accumulation of endocytic membranes around the Golgi apparatus, in which recycling endosomes concentrate. This peri-Golgi polarization has been documented by colocalization analysis of various membrane markers and applies also to active caspases associated with internalized receptor complexes. Hence, T lymphocytes show a diversion in the traffic of endocytic membranes after Fas stimulation that seems to resemble the polarization of membrane traffic after their activation.
引用
收藏
页码:600 / 615
页数:16
相关论文
共 52 条
[11]   Differential involvement of endocytic compartments in the biosynthetic traffic of apical proteins [J].
Cresawn, Kerry O. ;
Potter, Beth A. ;
Oztan, Asli ;
Guerriero, Christopher J. ;
Ihrke, Gudrun ;
Goldenring, James R. ;
Apodaca, Gerard ;
Weisz, Ora A. .
EMBO JOURNAL, 2007, 26 (16) :3737-3748
[12]   Membrane nanotubes: dynamic long-distance connections between animal cells [J].
Davis, Daniel M. ;
Sowinski, Stefanie .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2008, 9 (06) :431-436
[13]   Endocytosis of GPI-anchored proteins in human lymphocytes: Role of glycolipid-based domains, actin cytoskeleton, and protein kinases [J].
Deckert, M ;
Ticchioni, M ;
Bernard, A .
JOURNAL OF CELL BIOLOGY, 1996, 133 (04) :791-799
[14]   Endocytosis and signaling: An inseparable partnership [J].
Di Fiore, PP ;
De Camilli, P .
CELL, 2001, 106 (01) :1-4
[15]   The release of microparticles by apoptotic cells and their effects on macrophages [J].
Distler, JHW ;
Huber, LC ;
Hueber, AJ ;
Reich, CF ;
Gay, S ;
Distler, O ;
Pisetsky, DS .
APOPTOSIS, 2005, 10 (04) :731-741
[16]   CD46 plays a key role in tailoring innate immune recognition of apoptotic and necrotic cells [J].
Elward, K ;
Griffiths, M ;
Mizuno, M ;
Harris, CL ;
Neal, JW ;
Morgan, BP ;
Gasque, P .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (43) :36342-36354
[17]   CD95 death-inducing signaling complex formation and internalization occur in lipid rafts of type I and type II cells [J].
Eramo, A ;
Sargiacomo, M ;
Ricci-Vitiani, L ;
Todaro, M ;
Stassi, G ;
Messina, CGM ;
Parolini, I ;
Lotti, F ;
Sette, G ;
Peschle, C ;
De Maria, R .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2004, 34 (07) :1930-1940
[18]   Organelle intermixing and membrane scrambling in cell death [J].
Esposti, Mauro Degh .
PROGRAMMED CELL DEATH, GENERAL PRINCIPLES FOR STUDYING CELL DEATH, PT A, 2008, 442 :421-438
[19]   Cdc42 - the centre of polarity [J].
Etienne-Manneville, S .
JOURNAL OF CELL SCIENCE, 2004, 117 (08) :1291-1300
[20]   Release and intercellular transfer of cell surface CD81 via microparticles [J].
Fritzsching, B ;
Schwer, B ;
Kartenbeck, J ;
Pedal, A ;
Horejsi, V ;
Ott, M .
JOURNAL OF IMMUNOLOGY, 2002, 169 (10) :5531-5537